Drug Discovery and Cyclotron Research Center, Southern Tohoku Research Institute for Neuroscience, Koriyama, Japan.
Department of Radiology, National Center of Neurology and Psychiatry, Kodaira, Japan.
Brain Behav. 2023 Jul;13(7):e3092. doi: 10.1002/brb3.3092. Epub 2023 Jun 7.
Quantitative measures have been proposed to aid the visual interpretation of amyloid PET. Our objective was to develop and validate quantitative software that enables calculation of the Centiloid (CL) scale and Z-score for amyloid PET with F-florbetapir.
This software was developed as a toolbox in statistical parametric mapping 12 running on MATLAB Runtime. For each participant's amyloid PET, this software calculates the CL scale using the standard MRI-guided pipeline proposed by the Global Alzheimer's Association Interactive Network (GAAIN) and generates a Z-score map for comparison with a new amyloid-negative database constructed from 20 healthy controls. In 23 cognitively impaired patients with suspected Alzheimer's disease, Z-score values for a target cortical area from the new database were compared with those from the GAAIN database constructed from 13 healthy controls. The CL values obtained using low-dose CT of PET/CT equipment were then compared with those obtained using MRI.
The CL calculation was validated with the F-florbetapir dataset in the GAAIN repository. Z-score values obtained from the new database were significantly higher (mean ± standard deviation, 1.05 ± 0.77; p < .0001) than those obtained from the GAAIN database. The use of low-dose CT provided CL scales that were highly correlated with those obtained with MRI (R = .992) but showed a slight yet significant underestimation (-2.1 ± 4.2; p = .013).
Our quantification software provides the CL scale and Z-score for measuring overall and local amyloid accumulation with the use of MRI or low-dose CT.
已经提出了定量测量方法来辅助对淀粉样蛋白 PET 的视觉解读。我们的目标是开发和验证一种定量软件，该软件能够使用 F-氟比他滨计算淀粉样蛋白 PET 的 Centiloid（CL）量表和 Z 分数。
该软件作为在 MATLAB Runtime 上运行的统计参数映射 12 的工具箱进行开发。对于每个参与者的淀粉样蛋白 PET，该软件使用全球阿尔茨海默病协会互动网络（GAAIN）提出的标准 MRI 引导管道计算 CL 量表，并生成 Z 分数图，以便与从 20 名健康对照者构建的新的淀粉样蛋白阴性数据库进行比较。在 23 名认知障碍的疑似阿尔茨海默病患者中，将新数据库中目标皮质区域的 Z 分数值与从 13 名健康对照者构建的 GAAIN 数据库中的 Z 分数值进行比较。然后，将使用 PET/CT 设备的低剂量 CT 获得的 CL 值与使用 MRI 获得的 CL 值进行比较。
使用 GAAIN 存储库中的 F-氟比他滨数据集对 CL 计算进行了验证。从新数据库获得的 Z 分数值明显更高（均值±标准差，1.05±0.77；p<0.0001），高于从 GAAIN 数据库获得的值。使用低剂量 CT 提供的 CL 量表与使用 MRI 获得的 CL 量表高度相关（R=0.992），但存在轻微但显著的低估（-2.1±4.2；p=0.013）。
我们的定量软件提供了使用 MRI 或低剂量 CT 测量总体和局部淀粉样蛋白积聚的 CL 量表和 Z 分数。
