Minaiyan Mohsen, Pasandideh-Fetrat Parastoo, Sadeghi-Dinani Masoud, Talebi Ardeshir
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2023 Apr 27;12:105. doi: 10.4103/abr.abr_151_22. eCollection 2023.
Boiss. () is a flowering plant with several therapeutic properties including antiinflammatory, antioxidant, antimicrobial, and wound-healing activity. Regarding the side effects of drugs conventionally used for inflammatory bowel disease (IBD) treatment, we investigated the anticolitis properties of aqueous (SSAE) and hydroalcoholic (SSHE) extracts of on experimental colitis.
The colitis was induced using acetic acid (3%) and 2 h before ulcer induction, each group of rats received orally three doses (150, 300, and 600 mg/kg, p.o.) of SSAE or SSHE for the next 5 days. Dexamethasone (1 mg/kg, i.p.) and mesalazine (100 mg/kg, p.o.) were used as reference drugs. Different parameters including weight of colon/height, ulcer index, total colitis index, levels of myeloperoxidase (MPO) and malondialdehyde (MDA) were investigated.
Total phenolic contents were 4.3 ± 0.2 and 7.1 ± 0.4 mg/g equivalent to gallic acid for SSAE and SSHE respectively. Three applied doses of SSHE and the highest dose of SSAE (600 mg/kg) could reduce all the macroscopic and pathologic indices of colitis and the levels of MPO and MDA. Two lesser doses of SSAE (150, 300 mg/kg) however, couldn't diminish the histopathologic features of colitis and the values of MPO and MDA.
, especially SSHE, which also contained more phenolic compounds, had an ameliorating effect on ulcerative colitis and possibly exerts this effect through its antioxidant, antiinflammatory and wound healing properties. Further investigations are required to introduce this plant as a novel alternative herbal drug for colitis treatment.
Boiss.（）是一种开花植物，具有多种治疗特性，包括抗炎、抗氧化、抗菌和伤口愈合活性。鉴于传统用于治疗炎症性肠病（IBD）的药物存在副作用，我们研究了[植物名称]水提取物（SSAE）和水醇提取物（SSHE）对实验性结肠炎的抗结肠炎特性。
使用乙酸（3%）诱导结肠炎，在诱导溃疡前2小时，每组大鼠在接下来的5天内口服三剂（150、300和600毫克/千克，口服）SSAE或SSHE。地塞米松（1毫克/千克，腹腔注射）和美沙拉嗪（100毫克/千克，口服）用作参考药物。研究了不同参数，包括结肠重量/身高、溃疡指数、总结肠炎指数、髓过氧化物酶（MPO）和丙二醛（MDA）水平。
SSAE和SSHE的总酚含量分别为4.3±0.2和7.1±0.4毫克/克（相当于没食子酸）。SSHE的三个应用剂量和SSAE的最高剂量（600毫克/千克）可降低结肠炎的所有宏观和病理指标以及MPO和MDA水平。然而，SSAE的两个较低剂量（150、300毫克/千克）不能减轻结肠炎的组织病理学特征以及MPO和MDA值。
[植物名称]，尤其是含有更多酚类化合物的SSHE，对溃疡性结肠炎有改善作用，可能通过其抗氧化、抗炎和伤口愈合特性发挥这种作用。需要进一步研究将这种植物作为治疗结肠炎的新型替代草药药物。
