Hadavi-Siahboomi Mahdi, Yegdaneh Afsaneh, Talebi Ardeshir, Minaiyan Mohsen
School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2022 Dec 26;13:155. doi: 10.4103/ijpvm.ijpvm_50_22. eCollection 2022.
Ulcerative colitis (UC) is an inflammatory bowel disease that can be treated with many medications but they have various side effects and low cure rate. So, the need for finding novel drugs with better healing characters and less toxicity would be mandatory. (, Yarrow) has been traditionally used to treat bleeding, ulcers, wounds, liver, and bile disorders, and recently it has been shown to have anti-ulcer, analgesic, anti-inflammatory, antioxidant, and appetizing effects that make it as a good candidate for UC.
UC was induced with intra-rectal instillation of acetic acid. hydroalcoholic extract (AMHE, 200, 400, and 600 mg/kg/day) and essential oil (AMEO, 62.5, 125, and 250 μl/kg/day) were given to six groups of male Wistar rats for 5 days. Dexamethasone (1 mg/kg/day, intra-peritoneal) and mesalazine (100 mg/kg/day, orally) were used as reference drugs. Colon tissue specimens were separated for assessing macroscopic, pathologic, and biochemical markers.
For AMHE, 77.2 mg/g equivalent to gallic acid was obtained for total phenols. Main assessed markers, including ulcer index, total colitis index, colon weight/length ratio, rats' weight gain, and malondialdehyde levels were significantly improved in AMHE (400 and 600 mg/kg/day) and AMEO (125 and 250 μl/kg/day) groups compared to controls. Myeloperoxidase activity was only attenuated in AMHE groups significantly.
Both AMHE and AMEO were effective in healing experimental colitis. It seems antioxidant, anti-inflammatory, and anti-ulcer activities of Yarrow are responsible for these beneficial effects. Further studies are warranted to elucidate the exact mechanisms involved.
溃疡性结肠炎（UC）是一种炎症性肠病，可用多种药物治疗，但这些药物有各种副作用且治愈率低。因此，必须寻找具有更好愈合特性和更低毒性的新型药物。传统上，欧蓍草已被用于治疗出血、溃疡、伤口、肝脏和胆汁疾病，最近研究表明它具有抗溃疡、镇痛、抗炎、抗氧化和开胃作用，使其成为治疗UC的良好候选药物。
通过直肠内注入乙酸诱导UC。将六组雄性Wistar大鼠分别给予水醇提取物（AMHE，200、400和600mg/kg/天）和精油（AMEO，62.5、125和250μl/kg/天），持续5天。地塞米松（1mg/kg/天，腹腔注射）和美沙拉嗪（100mg/kg/天，口服）用作对照药物。分离结肠组织标本以评估宏观、病理和生化指标。
对于AMHE，总酚含量为77.2mg/g（相当于没食子酸）。与对照组相比，AMHE（400和600mg/kg/天）和AMEO（125和250μl/kg/天）组的主要评估指标，包括溃疡指数、全结肠炎指数、结肠重量/长度比、大鼠体重增加和丙二醛水平均有显著改善。髓过氧化物酶活性仅在AMHE组中显著降低。
AMHE和AMEO对实验性结肠炎均有治疗效果。欧蓍草的抗氧化、抗炎和抗溃疡活性可能是这些有益作用的原因。有必要进一步研究以阐明其中的确切机制。
