用于 HPV16/18 高危型 HPV 感染以外的女性宫颈癌筛查的甲基化检测的应用。
Utilization of methylation test for cervical cancer screening of non-HPV16/18 high-risk HPV infection in women.
机构信息
Department of Obstetrics & Gynecology, Changsha Hospital for Maternal & Child Health Care, affiliated to Hunan Normal University, Changsha, 410007, China.
Department of Medical Statistics, Hunan Hoomya Gene Technology Co., Ltd., Changsha, 410205, China.
出版信息
Future Oncol. 2023 Sep;19(28):1917-1927. doi: 10.2217/fon-2023-0226. Epub 2023 Jun 8.
To evaluate the clinical performance of methylation () and cytology for patients with non-HPV16/18 high-risk HPV (hrHPV) infection. Cervical exfoliated cells from 387 outpatients with non-HPV16/18 hrHPV - positive were collected for cytology and assays. The level increased with the severity of cytology and histopathology. For cervical intraepithelial neoplasia (CIN)CIN2+/CIN3+, the areas under the curve were both 0.87. The specificity and positive predictive value (PPV) of were greater than abnormal cytology (CIN2+ specificity: 75.5 vs 24.8%; PPV: 38.8 vs 18.7%; CIN3+ specificity: 69.3 vs 22.7%; PPV: 14.0 vs 6.7%). increased specificity and PPV for CIN2+/CIN3+ compared with cytology for women with non-HPV16/18 hrHPV (+).
评估非 HPV16/18 高危型 HPV（hrHPV）感染患者的甲基化（）和细胞学的临床性能。收集了 387 名非 HPV16/18 hrHPV 阳性的门诊患者的宫颈脱落细胞，进行细胞学和检测。水平随细胞学和组织病理学的严重程度而升高。对于宫颈上皮内瘤变（CIN）CIN2+/CIN3+，曲线下面积均为 0.87。的特异性和阳性预测值（PPV）均大于异常细胞学（CIN2+特异性：75.5%比 24.8%；PPV：38.8%比 18.7%；CIN3+特异性：69.3%比 22.7%；PPV：14.0%比 6.7%）。与非 HPV16/18 hrHPV（+）女性的细胞学相比，用于 CIN2+/CIN3+的特异性和 PPV 更高。
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