Song Yong, Fazleabas Asgerally T
Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, 49503, USA.
Reprod Sci. 2021 Jun;28(6):1626-1636. doi: 10.1007/s43032-021-00471-z. Epub 2021 Feb 2.
The endometrium is one of the most dynamic organs in the human body. Until now, cell lines have furthered the understanding of endometrial biology and associated diseases, but they failed to recapitulate the key physiological aspects of the endometrium, especially as it relates to its complex architecture and functions. Organoid culture systems have become an alternative approach to reproduce biological functions of tissues in vitro. Endometrial organoids have now been established from stem/progenitor cells and/or differentiated cells by several methods, which represents a promising tool to gain a deeper understanding of this dynamic organ. In this review, we will discuss the establishment, characteristics, applications, and potential challenges and directions of endometrial organoids.
子宫内膜是人体中最具活力的器官之一。到目前为止，细胞系有助于人们对子宫内膜生物学及相关疾病的理解，但它们未能重现子宫内膜的关键生理特征，尤其是涉及其复杂结构和功能的特征。类器官培养系统已成为在体外重现组织生物学功能的一种替代方法。目前已通过多种方法从干细胞/祖细胞和/或分化细胞建立了子宫内膜类器官，这是一种有望更深入了解这个动态器官的工具。在这篇综述中，我们将讨论子宫内膜类器官的建立、特征、应用以及潜在挑战和发展方向。
