Agwang Winnie, Nangendo Joanita, Nabikande Sherifah, Okello Tom, Tusabe Joan, Semitala Fred C, Kasasa Simon, Matovu Joseph K B
School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.
Clinical Epidemiology Unit, College of Health Sciences, Makerere University, Kampala, Uganda.
PLOS Glob Public Health. 2023 Jun 8;3(6):e0001191. doi: 10.1371/journal.pgph.0001191. eCollection 2023.
Pre-Exposure Prophylaxis (PrEP) is a known HIV prevention strategy for high-risk populations however, some high-risk communities have not yet fully embraced it. We sought to determine willingness to take PrEP and the associated factors among high-risk adolescent boys and young men (ABYM) in Masese fishing community, Jinja district, Eastern Uganda. We conducted a cross-sectional study, between October and November 2020, using a semi-structured questionnaire among ABYM aged 10-24 years in Masese fishing community, Eastern Uganda. We surveyed 479 participants, who had two or more sexual partners with inconsistent or no condom use. We carried out modified Poisson regression analysis to determine factors associated with willingness to take PrEP.Of 479 high-risk ABYM, 86.4% (n = 414) were willing to take PrEP. Confidence in PrEP safety (adj.PR = 1.56; 95%CI: 1.55, 2.24), availability of PrEP in areas easily accessible by ABYM (adj.PR = 1.40; 95%CI: 1.25, 1.57), and perceiving oneself as being at a very high risk of HIV infection (adj.PR = 1.11; 95%CI: 1.03, 1.20) were positively associated with willingness to take PrEP. On the other hand, being unmarried (adj.PR = 0.92; 95%CI: 0.87, 0.98) and earning more than USD 27 a month (adj.PR = 0.92; 95%CI: 0.87, 0.97) were negatively associated with willingness to take PrEP. There was high willingness to take PrEP among adolescent boys and young men in Masese fishing community. Confidence in PrEP safety, access to PrEP in their community and self-perception to be at high risk for HIV acquisition had a positive bearing on willingness to take PrEP while being unmarried and earning more than USD27 had a negative bearing on willingness to take PrEP. These findings suggest a need for target-specific interventions for unmarried men and those earning >USD27.
暴露前预防（PrEP）是一种针对高危人群的已知艾滋病预防策略，然而，一些高危社区尚未完全接受它。我们试图确定乌干达东部金贾区马塞塞渔业社区高危青少年男孩和年轻男性（ABYM）服用PrEP的意愿及相关因素。2020年10月至11月期间，我们在乌干达东部马塞塞渔业社区对10至24岁的ABYM进行了一项横断面研究，使用半结构化问卷。我们调查了479名有两个或更多性伴侣且使用避孕套情况不一致或未使用避孕套的参与者。我们进行了修正泊松回归分析，以确定与服用PrEP意愿相关的因素。在479名高危ABYM中，86.4%（n = 414）愿意服用PrEP。对PrEP安全性的信心（调整后PR = 1.56；95%置信区间：1.55，2.24）、ABYM在容易到达的地区可获得PrEP（调整后PR = 1.40；95%置信区间：1.25，1.57）以及认为自己感染艾滋病毒的风险非常高（调整后PR = 1.11；95%置信区间：1.03，1.20）与服用PrEP的意愿呈正相关。另一方面，未婚（调整后PR = 0.92；95%置信区间：0.87，0.98）和月收入超过27美元（调整后PR = 0.92；95%置信区间：0.87，0.97）与服用PrEP的意愿呈负相关。马塞塞渔业社区的青少年男孩和年轻男性服用PrEP的意愿较高。对PrEP安全性的信心、在其社区获得PrEP的机会以及自我认为感染艾滋病毒的风险高对服用PrEP的意愿有积极影响，而未婚和月收入超过27美元对服用PrEP的意愿有消极影响。这些发现表明，需要针对未婚男性和月收入超过27美元的人群进行有针对性的干预。
