Division of Gastroenterology, Hepatology and Nutrition (C.L.G.), Vanderbilt University Medical Center, Nashville.
Tennessee Center for AIDS Research (C.L.G.), Vanderbilt University Medical Center, Nashville.
Circ Res. 2023 Jun 9;132(12):1674-1691. doi: 10.1161/CIRCRESAHA.123.322055. Epub 2023 Jun 8.
Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and underlies the leading causes of morbidity and mortality, both within the United States and worldwide. Commensal microbiota are implicated in the development of cardiometabolic disease. Evidence suggests that the microbiome is relatively variable during infancy and early childhood, becoming more fixed in later childhood and adulthood. Effects of microbiota, both during early development, and in later life, may induce changes in host metabolism that modulate risk mechanisms and predispose toward the development of cardiometabolic disease. In this review, we summarize the factors that influence gut microbiome composition and function during early life and explore how changes in microbiota and microbial metabolism influence host metabolism and cardiometabolic risk throughout life. We highlight limitations in current methodology and approaches and outline state-of-the-art advances, which are improving research and building toward refined diagnosis and treatment options in microbiome-targeted therapies.
心血管代谢疾病包括心血管和代谢功能障碍，是美国乃至全球发病率和死亡率的主要原因。共生微生物群与心血管代谢疾病的发展有关。有证据表明，微生物组在婴儿期和幼儿期相对多变，在儿童后期和成年期变得更加固定。微生物组在早期发育和生命后期的影响可能会引起宿主代谢的变化，从而调节风险机制，并促使心血管代谢疾病的发生。在这篇综述中，我们总结了影响早期生命中肠道微生物组组成和功能的因素，并探讨了微生物组和微生物代谢的变化如何影响宿主代谢和整个生命周期的心血管代谢风险。我们强调了当前方法和方法的局限性，并概述了最先进的进展，这些进展正在改进研究，并朝着针对微生物组的治疗方法的精确诊断和治疗选择方向发展。
