Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India.
Ther Deliv. 2023 Mar;14(3):227-249. doi: 10.4155/tde-2023-0001. Epub 2023 Jun 9.
Periodontitis is a microbiological condition that affects the tissues supporting the teeth. The fundamental to effective periodontal therapy is choosing the suitable antimicrobial and anti-inflammatory agent, together with the proper route of drug administration and delivery system. Intra-periodontal pocket approach with nano drug-delivery systems (NDDS) such as polymeric nanoparticles, gold nanoparticles, silica nanoparticles, magnetic nanoparticles, liposomes, polymersomes, exosomes, nano micelles, niosome, solid lipid nanoparticles, nano lipid carriers, nanocomposites, nanogels, nanofibers, scaffolds, dendrimers, quantum dots, etc., will be appropriate route of drug administration and delivery system. This NDDS delivers the drugs at the site of infection to inhibit growth and promote tissue regeneration. The present review focused on providing comprehensive information on the NDDS for periodontitis, which enhanced therapeutic outcomes via intra-periodontal pocket delivery.
牙周炎是一种影响牙齿支持组织的微生物状况。有效的牙周病治疗的基础是选择合适的抗菌和抗炎药物，以及适当的药物给药途径和输送系统。牙周袋内途径与纳米药物输送系统（NDDS）结合，如聚合物纳米粒、金纳米粒、硅纳米粒、磁性纳米粒、脂质体、聚合物囊泡、外泌体、纳米胶束、囊泡、固体脂质纳米粒、纳米脂质载体、纳米复合材料、纳米凝胶、纳米纤维、支架、树枝状聚合物、量子点等，将是合适的药物给药途径和输送系统。这种 NDDS 将药物递送到感染部位，以抑制生长并促进组织再生。本综述重点介绍了用于牙周炎的 NDDS，通过牙周袋内给药提高了治疗效果。
