菠菜、芥菜和卷心菜叶中酚类化合物对小鼠的抗糖尿病作用。
antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice.
作者信息
Mehmood Arif, Zeb Alam, Ateeq Muhammad Khalil
机构信息
Department of Biotechnology, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan.
Department of Biochemistry, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan.
出版信息
Heliyon. 2023 May 27;9(6):e16616. doi: 10.1016/j.heliyon.2023.e16616. eCollection 2023 Jun.
Leafy vegetables are considered to have health-promoting potentials, mainly attributed to bioactive phenolic compounds. The antidiabetic effects of spinach, mustard, and cabbage were studied by feeding their phenolic-rich aqueous extracts to alloxan-induced diabetic mice. The antioxidant, biochemical, histopathological, and hematological indices of the control, diabetic, and treated mice were studied. Phenolic compounds present in the extracts were identified and quantified using HPLC-DAD. Results showed ten, nineteen, and eleven phenolic compounds in spinach, mustard, and cabbage leave aqueous extracts, respectively. The body weight, tissue total glutathione (GSH) contents, fasting blood sugar, liver function tests, renal function tests, and lipid profile of the mice were affected by diabetes and were significantly improved by the extract treatments. Likewise, hematological indices and tissues histological studies also showed recovery from diabetic stress in treated mice. The study's findings highlight that the selected leafy vegetables potentially mitigate diabetic complications. Among the studied vegetables, cabbage extract was comparatively more active in ameliorating diabetic stress.
叶菜类蔬菜被认为具有促进健康的潜力，这主要归因于生物活性酚类化合物。通过将富含酚类的水提取物喂给四氧嘧啶诱导的糖尿病小鼠，研究了菠菜、芥菜和卷心菜的抗糖尿病作用。对对照小鼠、糖尿病小鼠和经处理小鼠的抗氧化、生化、组织病理学和血液学指标进行了研究。使用高效液相色谱 - 二极管阵列检测器（HPLC - DAD）对提取物中存在的酚类化合物进行了鉴定和定量。结果表明，菠菜、芥菜和卷心菜叶水提取物中分别含有10种、19种和11种酚类化合物。小鼠的体重、组织总谷胱甘肽（GSH）含量、空腹血糖、肝功能测试、肾功能测试和血脂谱受到糖尿病的影响，而提取物处理后这些指标得到显著改善。同样，血液学指标和组织组织学研究也表明经处理的小鼠从糖尿病应激中恢复。该研究结果突出表明，所选叶菜类蔬菜有可能减轻糖尿病并发症。在所研究的蔬菜中，卷心菜提取物在改善糖尿病应激方面相对更具活性。
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