Entwistle C A, Rowe R C
J Pharm Pharmacol. 1979 May;31(5):269-72. doi: 10.1111/j.2042-7158.1979.tb13499.x.
Plasticizer/polymer interactions have been studied by measuring the intrinsic viscosities of both ethyl cellulose and hydroxypropyl methylcellulose in a series of dialkyl phthalates and in a series of liquid glycols respectively. A correlation was found between the intrinsic viscosity of the polymer/plasticizer solutions and the tensile strength, elongation at rupture and work done in stressing to failure of cast films--the mechanical properties being at a minimum when the intrinsic viscosity was at a maximum. This correlation held only within a homologous series of plasticizers and none was found for plasticizers of different structures. A relationship was found between the lowering of a calculated glass transition temperature of hydroxypropyl methylcellulose in the presence of the plasticizers propylene glycol, polyethylene glycol 200 and glycerol and the intrinsic viscosity of the corresponding solutions--the higher the viscosity the greater the lowering of the transition temperature.
通过分别测量乙基纤维素和羟丙基甲基纤维素在一系列邻苯二甲酸二烷基酯和一系列液态二醇中的特性粘度，对增塑剂与聚合物之间的相互作用进行了研究。研究发现，聚合物/增塑剂溶液的特性粘度与流延膜的拉伸强度、断裂伸长率以及拉伸至破坏时所做的功之间存在相关性——当特性粘度达到最大值时，机械性能处于最低水平。这种相关性仅在同系增塑剂系列中成立，对于不同结构的增塑剂则未发现这种相关性。研究发现，在增塑剂丙二醇、聚乙二醇200和甘油存在的情况下，羟丙基甲基纤维素的计算玻璃化转变温度的降低与相应溶液的特性粘度之间存在关系——粘度越高，转变温度降低幅度越大。
