羟羧氧酰胺菌素对人体粪便微生物区系的影响。
Effect of moxalactam on human fecal microflora.
作者信息
Benno Y, Shiragami N, Uchida K, Yoshida T, Mitsuoka T
出版信息
Antimicrob Agents Chemother. 1986 Jan;29(1):175-8. doi: 10.1128/AAC.29.1.175.
Abstract
Five healthy male adults received 2 g of moxalactam every 12 h for 7 days. The alterations of fecal microflora were investigated before, during, and after treatment with moxalactam. On day 7 of treatment, the number of total bacteria was decreased in all subjects. There was marked suppression of the obligate anaerobic bacteria and enterobacteria to undetectable levels, but the counts of Streptococcus spp. and Lactobacillus spp. increased. On day 7, two subjects had Clostridium innocuum and Clostridium ramosum in their feces but not Clostridium difficile. On day 7 after treatment, the counts of Streptococcus spp., enterobacteria, Lactobacillus spp., and Clostridium spp. in all subjects were still not normal.
摘要
五名健康成年男性连续7天每12小时接受2克拉氧头孢治疗。在接受拉氧头孢治疗前、治疗期间及治疗后，对粪便微生物群的变化进行了研究。在治疗的第7天，所有受试者的总细菌数量均减少。专性厌氧菌和肠杆菌被显著抑制至检测不到的水平，但链球菌属和乳杆菌属的数量增加。在第7天，两名受试者的粪便中有无害梭菌和多枝梭菌，但没有艰难梭菌。治疗后第7天，所有受试者的链球菌属、肠杆菌、乳杆菌属和梭菌属数量仍未恢复正常。
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