头孢曲松对粪便菌群的影响：微观形态测量分析
Effects of ceftriaxone on faecal flora: analysis by micromorphometry.
作者信息
Meijer B C, Kootstra G J, Geertsma D G, Wilkinson M H
机构信息
Laboratory for Medical Microbiology, State University, Groningen, The Netherlands.
出版信息
Epidemiol Infect. 1991 Jun;106(3):513-21. doi: 10.1017/s0950268800067571.
Abstract
In order to elucidate the effect of ceftriaxone therapy on the morphology of gut microflora, 11 human volunteers were treated with ceftriaxone, 1 g daily, given intramuscularly in one dose. Treatment continued for 5 days. Faecal microflora was analysed by digital image processing before, during and after the treatment period. We derived simple numerical parameters which describe the morphologic composition of the flora. They were significantly influenced by the antibiotic, and returned to their baseline values more than 7 days after treatment was stopped. The procedure holds promise for clinical application.
摘要
为阐明头孢曲松治疗对肠道微生物群形态的影响，11名人类志愿者接受了头孢曲松治疗，每日1克，单次肌肉注射。治疗持续5天。在治疗期之前、期间和之后，通过数字图像处理分析粪便微生物群。我们得出了描述微生物群形态组成的简单数值参数。它们受到抗生素的显著影响，在治疗停止后7天以上恢复到基线值。该程序具有临床应用前景。
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