Kiani Pantea, Mulder Kiki E W, Balikji Jessica, Kraneveld Aletta D, Garssen Johan, Verster Joris C
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Global Centre of Excellence Immunology, Nutricia Danone Research, 3584 CT Utrecht, The Netherlands.
J Clin Med. 2022 Jul 6;11(14):3933. doi: 10.3390/jcm11143933.
In addition to developing effective medicines and vaccines, pandemic preparedness also comprises general health-related, behavioral, and psychological aspects related to being more resistant in the case of future pandemics. In the context of the 2019 coronavirus (COVID-19) pandemic, recent research revealed that reduced perceived immune fitness was the best predictor of reporting more frequent and more severe COVID-19 symptoms. Up until now (June 2022), during the COVID-19 pandemic, the majority of patients who have been hospitalized were characterized as being overweight. It is therefore essential to further evaluate the relationship between body mass index (BMI) and immune fitness. This was performed by analyzing pooled data from previously published studies, conducted among N = 8586 Dutch adults. It was hypothesized that attaining a normal, healthy body weight is associated with optimal perceived immune fitness. The analysis revealed that a deviation from normal weight (i.e., having a BMI outside the range of 18.5 to 24.9 kg/m) was associated with significantly reduced perceived immune fitness, as assessed with the immune status questionnaire and a single item perceived immune fitness scale. The effects were significant for both underweight and overweight groups and most pronounced for the obese groups. The results suggest that attaining a normal, healthy body weight might significantly contribute to maintaining adequate perceived immune fitness. Therefore, attaining a normal body weight might be an essential component of pandemic preparedness and should be supported by creating awareness and promoting the importance of regular exercise and the consumption of healthy food.
除了研发有效的药物和疫苗外，大流行防范还包括与总体健康、行为以及心理相关的方面，这些方面有助于在未来大流行期间更具抵抗力。在2019冠状病毒病（COVID-19）大流行的背景下，最近的研究表明，较低的感知免疫健康状况是报告更频繁、更严重COVID-19症状的最佳预测指标。截至目前（2022年6月），在COVID-19大流行期间，大多数住院患者的特征是超重。因此，进一步评估体重指数（BMI）与免疫健康之间的关系至关重要。这是通过分析先前发表的针对N = 8586名荷兰成年人的研究汇总数据来进行的。研究假设是，达到正常、健康的体重与最佳的感知免疫健康状况相关。分析表明，与正常体重的偏差（即BMI超出18.5至24.9 kg/m范围）与显著降低的感知免疫健康状况相关，这是通过免疫状态问卷和单项感知免疫健康量表评估得出的。体重过轻和超重组的影响均显著，肥胖组最为明显。结果表明，达到正常、健康的体重可能对维持足够的感知免疫健康状况有显著贡献。因此，达到正常体重可能是大流行防范的一个重要组成部分，应该通过提高认识以及宣传定期锻炼和食用健康食品的重要性来加以支持。
