Balikji Jessica, Koyun Anna H, Hendriksen Pauline A, Kiani Pantea, Stock Ann-Kathrin, Garssen Johan, Hoogbergen Maarten M, Verster Joris C
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.
Cognitive Neurophysiology Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, University of Dresden, D-01307 Dresden, Germany.
J Clin Med. 2023 Apr 29;12(9):3205. doi: 10.3390/jcm12093205.
Previous studies in Dutch young adults revealed that individuals with self-reported impaired wound healing reported poorer mood, increased inattention and impulsivity, poorer quality of life, and poorer immune fitness compared to healthy controls. Another study revealed that the negative impact of lockdowns during the 2019 coronavirus disease (COVID-19) pandemic was significantly more profound among the impaired wound healing group than the control group. The purpose of the current study was to replicate and extend these findings among young adults living in Germany.
A retrospective, cross-sectional survey was conducted among N = 317 young adults living in Germany, 18-35 years old. They were allocated to the IWH group (N = 66) or the control group (N-251). Participants completed the Attention Control Scale, and mood, quality of life, and immune fitness were assessed with single-item ratings. All assessments were made for (1) the period before the COVID-19 pandemic, (2) the first lockdown period, March-May 2020, (3) the first no-lockdown period, summer 2020, (4) the second lockdown, November 2020 to May 2021, and (5) the second no-lockdown period, summer 2021.
The impaired wound healing group reported significantly poorer mood, quality of life, and immune fitness. The effects were evident before the pandemic. The impaired wound healing group scored significantly poorer on attention focusing, but no significant differences between the groups were found for attention shifting. During the pandemic, negative lockdown effects (i.e., further aggravation of mood and immune fitness and lower quality of life) were evident in both groups but significantly more profound in the impaired wound healing group. No differences between the groups were found for the no-lockdown periods.
Individuals with self-reported impaired wound healing have significantly poorer mood, attention focusing, and immune fitness and report a poorer quality of life than healthy controls. The impact of COVID-19 lockdowns was significantly more profound in the impaired wound-healing group.
此前针对荷兰年轻人的研究表明，自我报告伤口愈合受损的个体与健康对照组相比，情绪较差、注意力不集中和冲动性增加、生活质量较差且免疫健康状况较差。另一项研究表明，在2019冠状病毒病（COVID-19）大流行期间，封锁措施对伤口愈合受损组的负面影响比对对照组的影响要严重得多。本研究的目的是在生活在德国的年轻人中重复并扩展这些发现。
对317名年龄在18至35岁、生活在德国的年轻人进行了一项回顾性横断面调查。他们被分为伤口愈合受损组（N = 66）或对照组（N = 251）。参与者完成了注意力控制量表，并通过单项评分对情绪、生活质量和免疫健康状况进行了评估。所有评估针对以下五个时间段进行：（1）COVID-19大流行之前；（2）第一次封锁期，2020年3月至5月；（3）第一个非封锁期，2020年夏季；（4）第二次封锁期，2020年11月至2021年5月；（5）第二个非封锁期，2021年夏季。
伤口愈合受损组报告的情绪、生活质量和免疫健康状况明显较差。这些影响在大流行之前就很明显。伤口愈合受损组在注意力集中方面得分明显较低，但在注意力转移方面两组之间未发现显著差异。在大流行期间，两组均出现了负面的封锁效应（即情绪和免疫健康状况进一步恶化以及生活质量下降），但在伤口愈合受损组中更为明显。在非封锁期两组之间未发现差异。
自我报告伤口愈合受损的个体与健康对照组相比，情绪、注意力集中和免疫健康状况明显较差，生活质量也较低。COVID-19封锁措施对伤口愈合受损组的影响要严重得多。
