Nobori T
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1784-90.
We have been treating cancer since 1980 with a CO2 laser and since 1983 have added a Nd-YAG laser. We are applying the contact YAG laser with a new ceramics tip to cancer therapy. This ceramics laser is markedly different in its point of contact or noncontact from conventional lasers. In addition, one can use this laser at relatively low power (under 10 W). Also, we have recently developed a new ceramics tip for localized laser hyperthermia. The head and neck region is very irregular and present equipment is difficult to apply to this region. This type of hyperthermia was used on human thyroid anaplastic carcinoma transplanted into the necks of nude mice. In two of five nude mice decreased tumor size was observed 2 weeks after hyperthermia. Thereafter this technique has also been used in combination with radio-chemotherapy for patients with head and neck cancer. This localized laser hyperthermia was applied to the treatment of a patient with tongue cancer. This patient was given two localized hyperthermic treatments combined with 4,000 rads of radiation therapy and 5-Fu-administration for 4 weeks. A hemiglossectomy was performed using the contact YAG laser technique. A histological examination of the excised specimen failed to find evidence of tumor cells.
自1980年以来，我们一直使用二氧化碳激光治疗癌症，自1983年起又增加了钕钇铝石榴石激光。我们正在将带有新型陶瓷尖端的接触式钇铝石榴石激光应用于癌症治疗。这种陶瓷激光在接触或非接触方式上与传统激光有显著不同。此外，可以在相对较低的功率（低于10瓦）下使用这种激光。而且，我们最近开发了一种用于局部激光热疗的新型陶瓷尖端。头颈部区域非常不规则，现有的设备很难应用于该区域。这种热疗方法用于移植到裸鼠颈部的人类甲状腺未分化癌。在五只裸鼠中有两只，热疗后两周观察到肿瘤尺寸减小。此后，该技术也与头颈癌患者的放化疗联合使用。这种局部激光热疗应用于一名舌癌患者的治疗。该患者接受了两次局部热疗，同时结合4000拉德的放射治疗和连续4周的5-氟尿嘧啶给药。使用接触式钇铝石榴石激光技术进行了半舌切除术。对切除标本的组织学检查未发现肿瘤细胞的证据。
