El-Tonsy Mohamed Hany, El-Domyati Moetaz Mostafa, El-Sawy Ashraf Esmat, El-Din Wael Hosam, Anbar Tag El-Din Al-Sayed, Raouf Hamza A
Department of Dermatology, Faculty of Medicine, al-Minya University, Egypt.
Dermatol Online J. 2004 Oct 15;10(2):3.
It was observed that malignant tumor cells are more sensitive than normal cells to heat. Hyperthermia is known to be cytotoxic at temperatures above 41 degrees C and selectively lethal to cancer cells. The aim of the present study was to evaluate the therapeutic efficacy of continuous wave Nd:Yag laser-induced hyperthermia in treatment of basal cell carcinoma (BCC). The study was performed between April 1995 and August 2000 on 37 patients with BCC selected from of the outpatients of the dermatology clinic of al-Minya University Hospital. Patients were treated with continuous-wave Nd:Yag laser hyperthermia at 6-week intervals (laser output power was 10 W, spot size 8 mm, and irradiation time up to 1 minute). Following this treatment, 36 patients (97.3 %) were completely cured. Within a follow-up period of 3-5 years only one recurrence was encountered (2.7 %). Continuous wave Nd:Yag laser-induced hyperthermia should be considered as an alternative treatment for BCC. This simple, bloodless, outpatient procedure showed excellent efficacy and cosmetic result with minimal complication.
据观察，恶性肿瘤细胞比正常细胞对热更敏感。已知热疗在温度高于41摄氏度时具有细胞毒性，且对癌细胞具有选择性致死作用。本研究的目的是评估连续波Nd:Yag激光诱导的热疗对基底细胞癌（BCC）的治疗效果。该研究于1995年4月至2000年8月对从明亚大学医院皮肤科门诊挑选的37例基底细胞癌患者进行。患者每隔6周接受连续波Nd:Yag激光热疗（激光输出功率为10W，光斑大小8mm，照射时间长达1分钟）。经过该治疗后，36例患者（97.3%）完全治愈。在3至5年的随访期内仅出现1例复发（2.7%）。连续波Nd:Yag激光诱导的热疗应被视为基底细胞癌的一种替代治疗方法。这种简单、无血的门诊手术显示出极佳的疗效和美容效果，且并发症极少。
