LaMuraglia G M, Lacaine F, Malt R A
Ann Surg. 1986 Jul;204(1):89-93. doi: 10.1097/00000658-198607000-00013.
Polyamines are required for cell proliferation, and ornithine decarboxylase (ODC) is the first and probably rate-limiting enzyme in their synthesis. Tissue containing colonic or rectal adenocarcinomas (N = 34) or polyps (N = 6) and noninvolved paired colonic mucosa were obtained from fresh surgical specimens. ODC activity was elevated (mean: 320%) in both the cancer and polyps. In noninvolved colonic mucosa of tumor-bearing specimens, ODC activity was 165% that of colonic mucosa of non-neoplastic disease. Concentrations of polyamines in neoplasms were 121-214% increased, as compared with normal mucosa; those of spermidine and spermine varied inversely with the histological grade of the tumor. High levels of ODC activity and of polyamines were features of neoplasia, but not of malignancy alone. These characteristics of colonic neoplasia suggest its susceptibility to control by inhibition of ODC.
多胺是细胞增殖所必需的，鸟氨酸脱羧酶（ODC）是其合成过程中的首个且可能是限速酶。从新鲜手术标本中获取含有结肠或直肠腺癌（N = 34）或息肉（N = 6）以及未受累的配对结肠黏膜的组织。癌组织和息肉中的ODC活性均升高（平均：320%）。在携带肿瘤标本的未受累结肠黏膜中，ODC活性是无肿瘤疾病结肠黏膜的165%。与正常黏膜相比，肿瘤组织中的多胺浓度增加了121% - 214%；亚精胺和精胺的浓度与肿瘤的组织学分级呈负相关。高水平的ODC活性和多胺是肿瘤形成的特征，但并非仅为恶性肿瘤所特有。结肠肿瘤的这些特征表明其易受ODC抑制的控制。
