Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Sci Rep. 2023 Jun 9;13(1):9431. doi: 10.1038/s41598-023-36472-y.
Cancer and diabetes mellitus (DM) are diagnosed within the same individual more frequently and share common risk factors. Although diabetes among cancer patients may result in more aggressive clinical courses of cancer, there is limited evidence about its burden and associated factors. Hence, this study aimed to assess the burden of diabetes and prediabetes among cancer patients and its associated factors. Institution-based cross-sectional study was conducted at the University of Gondar comprehensive specialized hospital from 10 January to 10 March 2021. A systematic random sampling technique was used to select 423 cancer patients. The data was collected using a structured interviewer-administered questionnaire. Prediabetes and diabetes diagnosis was made based on World Health Organization (WHO) criteria. Bi-variable and multivariable binary logistic regression models were fitted to identify factors associated with the outcome. Adjusted Odds Ratio (AOR) with a 95% confidence interval was estimated to show the direction and strength of associations. Variables with a p-value less than 0.05 in the multivariable model were considered significantly associated with the outcome. The final analysis was based on 384 patients with cancer. The proportion of prediabetes and diabetes was 56.8% (95% CI 51.7, 61.7) and 16.7% (95% CI 13.3, 20.8), respectively. Alcohol consumption was found to increase the odds of elevated blood sugar among cancer patients (AOR: 1.96; 95%CI: 1.11, 3.46). The burden of prediabetes and diabetes is alarmingly high among cancer patients. Besides, alcohol consumption was found to increase the odds of having elevated blood sugar among cancer patients. Hence, it is essential to recognize cancer patients are at high risk of having elevated blood sugar and design strategies to integrate diabetes and cancer care.
癌症和糖尿病（DM）在同一患者中被诊断出的频率更高，且具有共同的危险因素。虽然癌症患者中的糖尿病可能导致癌症的临床过程更为激进，但关于其负担和相关因素的证据有限。因此，本研究旨在评估癌症患者中糖尿病和糖尿病前期的负担及其相关因素。 这是一项在 2021 年 1 月 10 日至 3 月 10 日期间于贡德尔大学综合专科医院进行的基于机构的横断面研究。采用系统随机抽样技术选择了 423 名癌症患者。使用结构式访谈员管理的问卷收集数据。根据世界卫生组织（WHO）标准诊断糖尿病前期和糖尿病。采用双变量和多变量二元逻辑回归模型来确定与结果相关的因素。使用调整后的优势比（AOR）和 95%置信区间来表示关联的方向和强度。在多变量模型中 p 值小于 0.05 的变量被认为与结果显著相关。最终分析基于 384 名癌症患者。糖尿病前期和糖尿病的比例分别为 56.8%（95%CI 51.7，61.7）和 16.7%（95%CI 13.3，20.8）。饮酒被发现会增加癌症患者血糖升高的几率（AOR：1.96；95%CI：1.11，3.46）。癌症患者中糖尿病前期和糖尿病的负担高得惊人。此外，饮酒被发现会增加癌症患者血糖升高的几率。因此，有必要认识到癌症患者有发生高血糖的高风险，并制定策略将糖尿病和癌症的护理整合起来。
