Schulsinger F, Knop J, Goodwin D W, Teasdale T W, Mikkelsen U
Arch Gen Psychiatry. 1986 Aug;43(8):755-60. doi: 10.1001/archpsyc.1986.01800080041006.
In a prospective longitudinal study of alcoholism, we applied the high-risk method using a Danish birth cohort (9125 consecutive deliveries, 1959 to 1961). From the cohort, 134 sons of alcoholic fathers (high-risk group) and 70 matched controls without parental alcoholism were selected for study. Extensive data were collected in a multidisciplinary etiologic approach. We report the social and psychological characteristics from a "premorbid" assessment when the subjects were 19 to 20 years old. The high-risk group reported more disrupted familial conditions during childhood than the control group. Both groups had a drinking pattern similar to that of the general Danish population at the same age. No alcoholic subjects were found. The high-risk group was characterized by poor verbal ability and impulsive behavior. We plan a follow-up examination of the sample.
在一项关于酗酒的前瞻性纵向研究中,我们采用高风险方法,利用丹麦一个出生队列(1959年至1961年连续9125例分娩)进行研究。从该队列中,选取了134名酗酒父亲的儿子(高风险组)和70名无父母酗酒的匹配对照组进行研究。采用多学科病因学方法收集了大量数据。我们报告了受试者19至20岁时“病前”评估的社会和心理特征。高风险组报告称,其童年时期的家庭状况比对照组更不稳定。两组的饮酒模式与丹麦同年龄的普通人群相似。未发现酗酒者。高风险组的特点是语言能力差和行为冲动。我们计划对该样本进行随访检查。