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季节性索诺兰蜂胶提取物及其主要成分的抗炎潜力。

Anti-Inflammatory Potential of Seasonal Sonoran Propolis Extracts and Some of Their Main Constituents.

机构信息

Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Avenida Universidad e Irigoyen, Caborca 83621, Mexico.

Research Center for Food and Development, CIAD, A.C. Carretera Gustavo Enrique Astiazaran Rosas No. 46, Hermosillo 83304, Mexico.

出版信息

Molecules. 2023 Jun 1;28(11):4496. doi: 10.3390/molecules28114496.

DOI:10.3390/molecules28114496
PMID:37298970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10254797/
Abstract

Biological properties of Sonoran propolis (SP) are influenced by harvest time. Caborca propolis showed cellular protective capacity against reactive oxygen species, which might be implicated in anti-inflammatory effects. However, the anti-inflammatory activity of SP has not been investigated so far. This study investigated the anti-inflammatory activity of previously characterized seasonal SP extracts (SPE) and some of their main constituents (SPC). The anti-inflammatory activity of SPE and SPC was evaluated by measuring nitric oxide (NO) production, protein denaturation inhibition, heat-induced hemolysis inhibition, and hypotonicity-induced hemolysis inhibition. SPE from spring, autumn, and winter showed a higher cytotoxic effect on RAW 264.7 cells (IC: 26.6 to 30.2 µg/mL) compared with summer extract (IC: 49.4 µg/mL). SPE from spring reduced the NO secretion to basal levels at the lowest concentration tested (5 µg/mL). SPE inhibited the protein denaturation by 79% to 100%, and autumn showed the highest inhibitory activity. SPE stabilized erythrocyte membrane against heat-induced and hypotonicity-induced hemolysis in a concentration-dependent manner. Results indicate that the flavonoids chrysin, galangin, and pinocembrin could contribute to the anti-inflammatory activity of SPE and that the harvest time influences such a property. This study presents evidence of SPE pharmacological potential and some of their constituents.

摘要

索诺兰蜂胶（SP）的生物学特性受收获时间的影响。卡博卡蜂胶显示出对活性氧的细胞保护能力，这可能与抗炎作用有关。然而，SP 的抗炎活性尚未得到研究。本研究调查了先前表征的季节性 SP 提取物（SPE）及其一些主要成分（SPC）的抗炎活性。通过测量一氧化氮（NO）产生、蛋白质变性抑制、热诱导溶血抑制和低渗性溶血抑制来评估 SPE 和 SPC 的抗炎活性。与夏季提取物（IC：49.4 µg/mL）相比，来自春季、秋季和冬季的 SPE 对 RAW 264.7 细胞的细胞毒性作用更高（IC：26.6 至 30.2 µg/mL）。来自春季的 SPE 在测试的最低浓度（5 µg/mL）下将 NO 分泌降低至基础水平。SPE 抑制蛋白质变性 79%至 100%，秋季表现出最高的抑制活性。SPE 以浓度依赖的方式稳定红细胞膜，防止热诱导和低渗性溶血。结果表明，类黄酮白杨素、柽柳素和 pinocembrin 可能有助于 SPE 的抗炎活性，并且收获时间会影响这种特性。本研究提供了 SPE 药理潜力及其一些成分的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/e473bbd4c99f/molecules-28-04496-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/087009a125d1/molecules-28-04496-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/d959eec8c510/molecules-28-04496-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/394807a1c1a4/molecules-28-04496-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/e473bbd4c99f/molecules-28-04496-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/087009a125d1/molecules-28-04496-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/d959eec8c510/molecules-28-04496-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/394807a1c1a4/molecules-28-04496-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/10254797/e473bbd4c99f/molecules-28-04496-g004.jpg

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