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通过可逆加成-断裂链转移（RAFT）聚合制备的三亲水性统计三元共聚物：在水溶液中的合成与性能

Triple Hydrophilic Statistical Terpolymers via RAFT Polymerization: Synthesis and Properties in Aqueous Solutions.

作者信息

Vagenas Dimitrios, Pispas Stergios

机构信息

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., 11635 Athens, Greece.

出版信息

Polymers (Basel). 2023 May 29;15(11):2492. doi: 10.3390/polym15112492.

DOI:10.3390/polym15112492
PMID:37299291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10255189/
Abstract

In this work, we report the synthesis of novel triple hydrophilic statistical terpolymers consisting of three different methacrylate monomers with varying degrees of responsivity to solution conditions. Terpolymers of the type poly(di(ethylene glycol) methyl ether methacrylate-co-2-(dimethylamino)ethylmethacrylate-co-oligoethylene glycol methyl ether methacrylate), P(DEGMA-co-DMAEMA-co-OEGMA), and of different compositions, were prepared by using the RAFT methodology. Their molecular characterization was carried out using size exclusion chromatography (SEC) and spectroscopic techniques, including H-NMR and ATR-FTIR. Studies in dilute aqueous media by dynamic and electrophoretic light scattering (DLS and ELS) show their potential responsiveness regarding changes in temperature, pH, and kosmotropic salt concentration. Finally, the change in hydrophilic/hydrophobic balance of the formed terpolymer nanoparticles during heating and cooling was studied using fluorescence spectroscopy (FS) in conjunction with pyrene giving additional information on the responsiveness and internal structure of the self-assembled nanoaggregates.

摘要

在本工作中，我们报道了由三种对溶液条件具有不同响应程度的不同甲基丙烯酸酯单体组成的新型三亲水性统计三元共聚物的合成。通过可逆加成-断裂链转移（RAFT）方法制备了聚（二（乙二醇）甲基醚甲基丙烯酸酯-共-2-（二甲基氨基）乙基甲基丙烯酸酯-共-低聚乙二醇甲基醚甲基丙烯酸酯）类型的三元共聚物P（DEGMA-共-DMAEMA-共-OEGMA）及其不同组成。使用尺寸排阻色谱法（SEC）和光谱技术（包括氢核磁共振（H-NMR）和衰减全反射傅里叶变换红外光谱（ATR-FTIR））对其进行分子表征。通过动态光散射和电泳光散射（DLS和ELS）在稀水介质中的研究表明，它们在温度、pH值和促溶盐浓度变化方面具有潜在的响应性。最后，结合芘使用荧光光谱法（FS）研究了加热和冷却过程中形成的三元共聚物纳米颗粒亲水性/疏水性平衡的变化，从而提供了关于自组装纳米聚集体的响应性和内部结构的更多信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/c617fef55a87/polymers-15-02492-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/b4ba483ab6f0/polymers-15-02492-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/3ef52e24ca77/polymers-15-02492-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/507c2faf4c76/polymers-15-02492-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/eb7b0aff283a/polymers-15-02492-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/03527221d1b8/polymers-15-02492-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/6a7baf0fe072/polymers-15-02492-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/d96a24860401/polymers-15-02492-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/67487ba4fbfd/polymers-15-02492-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/e77ec1f20f16/polymers-15-02492-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/59b8be3a85d2/polymers-15-02492-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/c617fef55a87/polymers-15-02492-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/b4ba483ab6f0/polymers-15-02492-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/3ef52e24ca77/polymers-15-02492-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/507c2faf4c76/polymers-15-02492-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/eb7b0aff283a/polymers-15-02492-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/03527221d1b8/polymers-15-02492-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/6a7baf0fe072/polymers-15-02492-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/d96a24860401/polymers-15-02492-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/67487ba4fbfd/polymers-15-02492-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/e77ec1f20f16/polymers-15-02492-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/59b8be3a85d2/polymers-15-02492-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1572/10255189/c617fef55a87/polymers-15-02492-g010.jpg

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