Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Health Research Authority, Holland Drive, Newcastle upon Tyne NE2 4NQ, UK.
Nutrients. 2023 May 23;15(11):2418. doi: 10.3390/nu15112418.
Coffeeberry extract, rich in chlorogenic acids, shows promise in improving mood and cognition, particularly when co-supplemented with phenolic compounds. However, limited work has considered the effects of coffeeberry in isolation, especially at low doses.
The current study investigated the effect of low and moderate doses of coffeeberry extract on cognition and mood.
This randomized, double-blind, placebo-controlled crossover design investigated three active beverages on a sample of 72 healthy adults aged 18-49 years. The investigational beverages contained 100 mg or 300 mg coffeeberry extract (standardized to 40% chlorogenic acid), or 75 mg caffeine (positive control). Cognition, mood, and subjective energy were measured at baseline and then again at 60 and 120 min post-treatment.
Analysis revealed no effect of 300 mg coffeeberry extract, while 100 mg resulted in increased mental fatigue during the performance of cognitively demanding tasks ( = 0.025) and decreased accuracy on a task of sustained attention ( = 0.003), compared to placebo, at 60 min post dose.
Administration of 100 mg and 300 mg coffeeberry extracts revealed limited, transient negative effects following 100 mg coffeeberry. Given the large number of outcome measures analysed and the absence of findings following the 300 mg dose, these negative findings should be interpreted with caution. Overall, the findings of the current study suggest that coffeeberry extract at a low or moderate dose does not have a beneficial effect on mood, mental and physical energy levels, or cognition; higher doses, as have been administered previously, may be more effective.
富含绿原酸的咖啡浆果提取物在改善情绪和认知方面显示出良好的效果，尤其是与酚类化合物共同补充时。然而，很少有研究单独考虑咖啡浆果的作用，特别是在低剂量时。
本研究旨在调查低剂量和中剂量咖啡浆果提取物对认知和情绪的影响。
这项随机、双盲、安慰剂对照交叉设计研究了三种含有 100mg 或 300mg 咖啡浆果提取物（标准化至 40%绿原酸）或 75mg 咖啡因（阳性对照）的活性饮料对 72 名年龄在 18-49 岁之间的健康成年人样本的影响。在基线和治疗后 60 分钟和 120 分钟时，分别测量认知、情绪和主观能量。
分析结果显示，300mg 咖啡浆果提取物没有效果，而 100mg 咖啡浆果提取物在执行认知要求高的任务时导致心理疲劳增加（ = 0.025），在持续注意力任务中的准确性降低（ = 0.003），与安慰剂相比，在剂量后 60 分钟。
给予 100mg 和 300mg 咖啡浆果提取物后，100mg 咖啡浆果提取物会产生短暂的、有限的负面影响。考虑到分析的大量结果测量和 300mg 剂量后没有发现结果，这些负面发现应谨慎解释。总的来说，本研究的结果表明，低剂量或中剂量的咖啡浆果提取物对情绪、心理和体力能量水平或认知没有有益的影响；以前给予的更高剂量可能更有效。
