Health Care Food Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan.
Biological Science Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan.
Nutrients. 2018 Sep 20;10(10):1337. doi: 10.3390/nu10101337.
(1) Background: Chlorogenic acids (CGAs) have been attracting interest of late, owing to their health benefits. Here, we performed a randomized, double-blind, placebo-controlled trial to investigate whether CGAs improved cognitive function in humans. (2) Methods: Thirty-eight healthy participants were assigned to either the CGA group, which was given CGA-added beverage daily for 16 weeks, or the placebo group. Cognitive functions were assessed using the Japanese version of the CNS Vital Signs (Cognitrax). (3) Results: The CGA group showed significant increase in the Cognitrax domain scores for motor speed, psychomotor speed, and executive function compared with the placebo group, as well as an improvement in the shifting attention test scores. In blood analysis, the CGA group showed increased levels of apolipoprotein A1 and transthyretin, both of which are putative biomarkers for early-stage cognitive decline. (4) Conclusions: These results suggest that CGAs may improve some cognitive functions, which would help in the efficient performance of complex tasks.
（1）背景：由于具有健康益处，近年来，绿原酸（CGAs）受到了广泛关注。在此，我们进行了一项随机、双盲、安慰剂对照试验，旨在研究 CGAs 是否能改善人类的认知功能。（2）方法：将 38 名健康参与者分为 CGA 组和安慰剂组，CGA 组每天饮用添加 CGAs 的饮料，持续 16 周，安慰剂组则饮用安慰剂。使用日本版中枢神经系统生命体征（Cognitrax）评估认知功能。（3）结果：与安慰剂组相比，CGA 组在运动速度、精神运动速度和执行功能的 Cognitrax 域评分上均有显著提高，并且注意力转换测试的评分也有所改善。在血液分析中，CGA 组的载脂蛋白 A1 和转甲状腺素蛋白水平升高，这两种蛋白均是认知能力下降早期的潜在生物标志物。（4）结论：这些结果表明，CGAs 可能改善某些认知功能，这有助于高效完成复杂任务。
