Department of Epidemiology and Health Statistics, School of Public Health of Qingdao University, 308 Ningxia Road, Qingdao 266071, China.
School of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Nutrients. 2023 May 30;15(11):2549. doi: 10.3390/nu15112549.
A relationship may exist between selenium and kidney calculi, but there is a lack of research in this field at present. Our study explored the relationship between the serum selenium level and a medical history of adult kidney calculi. We utilized data from the National Health and Nutrition Examination Survey conducted between 2011 and 2016. Participants self-reported their history of kidney stones, while serum selenium levels were measured using inductively coupled plasma dynamic reaction cell mass spectrometry. Our findings indicate a negative correlation between serum selenium levels and the risk of kidney stone history. In the multiple-adjusted model, the lowest serum selenium level group had a higher risk than the other groups. The odds ratio (95% confidence interval) of ever having kidney stones for the highest serum selenium level group was 0.54 (0.33-0.88). In the results of stratified analysis, this relationship was still significant in the groups of women and those 40-59 years. We also found that as a nonlinear dose-response relationship between serum selenium levels and the history of kidney stones disease. In our research, we found that people with higher serum selenium levels had a lower risk of having a history of kidney stones. We concluded that selenium may have a protective effect on kidney stones. In the future, more population studies are needed to explore the relationship between selenium and kidney stones.
硒与肾结石之间可能存在关系，但目前该领域的研究还很缺乏。本研究探讨了血清硒水平与成人肾结石病史之间的关系。我们利用了 2011 年至 2016 年期间进行的国家健康和营养检查调查的数据。参与者自我报告了肾结石病史，而血清硒水平则使用电感耦合等离子体动态反应池质谱法进行测量。我们的研究结果表明，血清硒水平与肾结石病史的风险呈负相关。在多因素调整模型中，血清硒水平最低的组发生肾结石病史的风险高于其他组。血清硒水平最高组发生肾结石病史的比值比（95%置信区间）为 0.54（0.33-0.88）。在分层分析的结果中，这种关系在女性和 40-59 岁的人群中仍然显著。我们还发现，血清硒水平与肾结石病史之间存在非线性剂量反应关系。在我们的研究中，我们发现血清硒水平较高的人发生肾结石病史的风险较低。我们得出结论，硒可能对肾结石有保护作用。未来需要更多的人群研究来探索硒与肾结石之间的关系。
