Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Ann Med. 2022 Dec;54(1):1627-1635. doi: 10.1080/07853890.2022.2085882.
Urolithiasis is one of the most common diseases in urology, with a lifetime prevalence of 14% and is more prevalent in males compared to females. We designed to explore sex disparities in the Chinese population to provide evidence for prevention measures and mechanisms of stone formation.
A total of 98232 Chinese individuals who had undergone a comprehensive examination in 2017 were included. Fully adjusted odds ratios for kidney stones were measured using restricted cubic splines. Multiple imputations was applied for missing values. Propensity score matching was utilised for sensitivity analysis.
Among the 98232 included participants, 42762 participants (43.53%) were females and 55470 participants (56.47%) were males. Patients' factors might cast an influence on the development of kidney stone disease distinctly between the two genders. A risk factor for one gender might have no effect on the other gender. The risk for urolithiasis in females continuously rises as ageing, while for males the risk presents a trend to ascend until the age of around 53 and then descend.
Patients' factors might influence the development of kidney stones distinctly between the two genders. As age grew, the risk to develop kidney stones in females continuously ascended, while the risk in males presented a trend to ascend and then descend, which was presumably related to the weakening of the androgen signals.Key messagesWe found that patients' factors might cast an influence on the development of kidney stone disease distinctly between the two sexes.The association between age and urolithiasis presents distinct trends in the two sexesThe results will provide evidence to explore the mechanisms underlying such differences can cast light on potential therapeutic targets and promote the development of tailored therapy strategies in prospect.
尿石症是泌尿外科最常见的疾病之一，终生患病率为 14%，男性比女性更为常见。我们旨在探讨中国人群中的性别差异，为预防措施和结石形成机制提供证据。
共纳入 2017 年接受全面检查的 98232 名中国个体。使用限制性立方样条测量肾结石的全调整优势比。对缺失值采用多重插补法。采用倾向评分匹配进行敏感性分析。
在纳入的 98232 名参与者中，42762 名（43.53%）为女性，55470 名（56.47%）为男性。患者因素可能在性别间明显影响肾结石疾病的发展。一个性别的危险因素可能对另一个性别没有影响。女性患尿石症的风险随着年龄的增长而持续上升，而男性的风险则呈现出先上升后下降的趋势，直至约 53 岁。
患者因素可能在性别间明显影响肾结石的发生。随着年龄的增长，女性发生肾结石的风险持续上升，而男性的风险则呈现出先上升后下降的趋势，这可能与雄激素信号减弱有关。
我们发现，患者因素可能在性别间明显影响肾结石疾病的发生。
年龄与尿石症之间的关联在两性中呈现出明显不同的趋势。
这些结果将为探索潜在的治疗靶点提供证据，并有望促进个体化治疗策略的发展。
