白内障摘除术与痴呆风险的关联——一项系统评价和荟萃分析
Association of cataract extraction and the risk of dementia-A systematic review and meta-analysis.
作者信息
Zhang Qiao, Ju Yuan, Zheng Wei, Xie Lulu, Wang Xi, Ren Huanhuan, Chen Zhipeng, Liu Xingtong, Bai Xiaolin, Fan Ruile
机构信息
College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Department of Ophthalmology, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
出版信息
Front Aging Neurosci. 2023 May 25;15:1168449. doi: 10.3389/fnagi.2023.1168449. eCollection 2023.
OBJECTIVES
This research aims to investigate if cataract extraction lowers the risk of all-cause dementia.
METHODS
Original literature on cataract surgery associated with all-cause dementia as of November 27, 2022, was searched in several commonly used databases. Manual review was used to include eligible studies. Stata software (version 16) was used to perform statistical analysis on pertinent data. Publication bias can be precisely evaluated using funnel plots and Egger's test.
RESULTS
In the meta-analysis of 4 cohort studies with 245,299 participants. Pooled analysis indicated that cataract surgery was linked to a lower incidence of all-cause dementia (OR = 0.77, 95%CI: 0.66-0.89; = 54.7%; < 0.001). Cataract surgery was linked to a lower risk of AD (OR = 0.60, 95%CI: 0.35-1.02; = 60.2%; < 0.001).
CONCLUSIONS
Cataract surgery is linked to a lower incidence of all-cause dementia and Alzheimer's disease. A cataract is a reversible visual impairment. Cataract surgery may be a protective factor against the onset of all-cause dementia and can reduce the economic and family burden caused by all-cause dementia worldwide. Given the restricted pool of included studies, our findings necessitate meticulous interpretation.
SYSTEMATIC REVIEW REGISTRATION
http://www.crd.york.ac.uk/prospero retrieve registration details by searching CRD4202379371.
目的
本研究旨在调查白内障摘除术是否能降低全因性痴呆的风险。
方法
在几个常用数据库中检索截至2022年11月27日与全因性痴呆相关的白内障手术原始文献。采用人工审核纳入符合条件的研究。使用Stata软件（版本16）对相关数据进行统计分析。可通过漏斗图和Egger检验精确评估发表偏倚。
结果
在对4项队列研究（共245,299名参与者）的荟萃分析中。汇总分析表明，白内障手术与全因性痴呆的较低发病率相关（比值比=0.77，95%置信区间：0.66-0.89；I²=54.7%；P<0.001）。白内障手术与阿尔茨海默病的较低风险相关（比值比=0.60，95%置信区间：0.35-1.02；I²=60.2%；P<0.001）。
结论
白内障手术与全因性痴呆和阿尔茨海默病的较低发病率相关。白内障是一种可逆转的视力损害。白内障手术可能是预防全因性痴呆发病的一个保护因素，并可减轻全球范围内全因性痴呆所造成的经济和家庭负担。鉴于纳入研究的样本有限，我们的研究结果需要谨慎解读。
系统评价注册
http://www.crd.york.ac.uk/prospero ，通过搜索CRD4202379371检索注册详情。
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