Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka University, Gurugram, India.
Department of Pharmaceutical Sciences, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, Haryana, India.
Oncol Res. 2023 Feb 3;30(5):221-230. doi: 10.32604/or.2022.027549. eCollection 2022.
Kinase inhibitors are a significant and continuously developing division of target therapeutics. The drug discovery and improvement efforts have examined numerous attempts to target the signaling pathway of kinases. The Kinase inhibitors have been heralded as a game-changer in cancer treatment. For developing kinase inhibitors as a treatment for various non-malignant disorders like auto-immune diseases, is currently undergoing extensive research. It may be beneficial to investigate whether cell-specific kinase inhibitor administration enhances therapeutic efficacy and decreases adverse effects. The goal of the current review is to gain insight into the role of kinase inhibitors in facilitating effective target drug delivery for the treatment of various anti-inflammatory, auto-immune, and anticancer disorders. The aim of this review is also to shed light on drug discovery approaches for kinase inhibitors, their mode of action, and delivery approaches. The variation in the binding of kinases bestows different target approaches in drug design, which can be employed for designing the targeted molecules. Several target sites have been studied, exceeding the design of drugs for various diseases like cancer, Alzheimer's, rheumatoid arthritis, etc. Diverse delivery approaches have also been studied for the targeted application of kinase inhibitors.
激酶抑制剂是靶向治疗的一个重要且不断发展的分支。药物发现和改进的努力已经检验了许多尝试靶向激酶信号通路的方法。激酶抑制剂在癌症治疗中被称为游戏规则的改变者。目前正在进行广泛的研究，将激酶抑制剂开发为治疗各种非恶性疾病（如自身免疫性疾病）的方法。研究细胞特异性激酶抑制剂给药是否可以提高治疗效果并降低不良反应可能是有益的。本综述的目的是深入了解激酶抑制剂在促进有效靶向药物输送以治疗各种抗炎、自身免疫和抗癌疾病方面的作用。本综述的目的还在于阐明激酶抑制剂的药物发现方法、作用模式和递药方法。激酶的结合变异性赋予了药物设计中的不同靶标方法，这些方法可用于设计靶向分子。已经研究了许多靶标位点，超过了针对各种疾病（如癌症、阿尔茨海默病、类风湿性关节炎等）的药物设计。还研究了多种递药方法，以实现激酶抑制剂的靶向应用。
