Vahabi Arman, Öztürk Anıl Murat
Department of Orthopaedics and Traumatology, Ege University School of Medicine, Izmir, Turkey.
MethodsX. 2023 May 26;10:102231. doi: 10.1016/j.mex.2023.102231. eCollection 2023.
Research on spinal cord injuries is an important and living topic that raises many critical questions that need to be addressed. While numerous articles have compiled and compared various models of spinal cord injuries, there is limited comprehensive guide with clear instructions available for researchers who are unfamiliar with clip compression model. This model creates acute compression damage in spinal cord, which aims to mimic the nature of traumatic spinal cord damage in humans. Purpose of this article is to share our experience on clip compression model, with experience gained from more than 150 animals, and to provide guidance for researchers with lack of experience who wish to design studies with this model. We have defined several key variables, as well as the difficulties that may arise when applying this model.-Proper preparation, good infrastructure and necessary tools and knowledge of anatomy related is essential to the success of this model.-Good exposure with non-bleeding surgical site is key factor for surgical step.-Postoperative care is particularly challenging, and researchers should consider extending their studies over a reasonable time period to ensure that appropriate care could be provided.
脊髓损伤研究是一个重要且热门的话题，引发了许多需要解决的关键问题。虽然已有大量文章汇编并比较了各种脊髓损伤模型，但对于不熟悉夹闭压迫模型的研究人员来说，可用的清晰说明的综合指南却很有限。该模型会在脊髓中造成急性压迫损伤，旨在模拟人类创伤性脊髓损伤的本质。本文的目的是分享我们在夹闭压迫模型方面的经验，这些经验来自150多只动物，并为缺乏经验且希望使用该模型设计研究的研究人员提供指导。我们定义了几个关键变量，以及应用该模型时可能出现的困难。——正确的准备、良好的基础设施、必要的工具以及相关解剖学知识对该模型的成功至关重要。——手术部位无出血的良好暴露是手术步骤的关键因素。——术后护理尤其具有挑战性，研究人员应考虑在合理的时间段内延长他们的研究，以确保能够提供适当的护理。
