实验大鼠脊髓损伤模型
Experimental Models of Spinal Cord Injury in Laboratory Rats.
作者信息
Minakov A N, Chernov A S, Asutin D S, Konovalov N A, Telegin G B
机构信息
Branch of Shemyakin and Ovchinnikov institute of bioorganic chemistry Russian academy of sciences, Prospekt Nauki, 6, Moscow region, Pushchino, 142290, Russia.
Federal State Autonomous Institution «N .N. Burdenko National Scientific and Practical Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, 4th Tverskaya-Yamskaya Str., 16, Moscow, 125047, Russia.
出版信息
Acta Naturae. 2018 Jul-Sep;10(3):4-10.
Abstract
Pathologies associated with spinal cord injury are some of the leading diseases in the world. The search for new therapeutic agents and 3D biodegradable materials for the recovery of spinal cord functions is a topical issue. In this review, we have summarized the literature data on the most common experimental models of spinal cord injury in laboratory rats and analyzed the experience of using 3D biodegradable materials (scaffolds) in experimental studies of spinal trauma. The advantages and disadvantages of the described models are systematically analyzed in this review.
摘要
与脊髓损伤相关的病症是世界上一些主要疾病。寻找用于恢复脊髓功能的新型治疗药物和3D可生物降解材料是一个热门问题。在本综述中，我们总结了关于实验室大鼠脊髓损伤最常见实验模型的文献数据，并分析了在脊柱创伤实验研究中使用3D可生物降解材料（支架）的经验。本综述系统分析了所述模型的优缺点。
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