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急性脊髓压迫持续时间对大鼠新急性脊髓损伤模型的影响。

Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat.

作者信息

Rivlin A S, Tator C H

出版信息

Surg Neurol. 1978 Jul;10(1):38-43.

PMID:684604
Abstract

The effect of duration of acute compression of the spinal cord was assessed in a new model in the rat. The spinal cord was acutely compressed for varying times by a modified aneurysm clip which produced a compression force of 180 grams. The effect of duration of compression was measured by the inclined plane method of assessing the animals' clinical performance. The results showed a linear relationship between log compression time and clinical performance. Thus, the clinical effect of acute compression of the spinal cord injury is inversely related to duration of compression time and the relationship has been precisely quantified. These results suggest that persisting compression should be relieved as soon as possible in order to improve recovery.

摘要

在一种新的大鼠模型中评估了急性脊髓压迫持续时间的影响。通过一个产生180克压力的改良动脉瘤夹对脊髓进行不同时间的急性压迫。压迫持续时间的影响通过评估动物临床表现的斜面法来测量。结果显示对数压缩时间与临床表现之间存在线性关系。因此,急性脊髓损伤压迫的临床效果与压迫时间呈负相关,且这种关系已得到精确量化。这些结果表明,为了促进恢复,应尽快解除持续的压迫。

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