Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
J Mater Chem B. 2023 Aug 24;11(33):7933-7941. doi: 10.1039/d2tb02688k.
A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene--maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serves as a universal adhesive material for the construction of multicomponent hybrid nanomaterials. As a proof of concept, gold nanorods (AuNRs) and single-walled carbon nanotubes (SWCNTs) are initially coated with PiBMAD. Subsequently, viral capsid proteins from the Cowpea Chlorotic Mottle Virus (CCMV) assemble around the nano-objects templated by the negative charges of the glue. With virtually unchanged properties of the rods and tubes, the hybrid materials might show improved biocompatibility and can be used in future studies toward cell uptake and delivery.
报道了一种基于病毒蛋白的杂化纳米材料的通用构建策略，该策略受贻贝黏附启发，使用了一种高分子黏合剂。设计了具有多巴胺修饰的商品化聚异丁烯-马来酸酐（PiBMA）作为这种高分子黏合剂，它可作为构建多组分杂化纳米材料的通用黏附材料。作为概念验证，首先用 PiBMAD 包覆金纳米棒（AuNRs）和单壁碳纳米管（SWCNTs）。随后，来自豇豆花叶病毒（CCMV）的病毒衣壳蛋白在黏合剂的负电荷模板的作用下围绕纳米物体组装。在棒和管的性质几乎不变的情况下，杂化材料可能显示出更好的生物相容性，并可用于未来的细胞摄取和递药研究。
