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系统性红斑狼疮中脑萎缩的快速发展

Rapid development of cerebral atrophy in systemic lupus erythematosus.

作者信息

Gordon T, Maddison P J, Isenberg D A

出版信息

Br J Rheumatol. 1986 Aug;25(3):296-9. doi: 10.1093/rheumatology/25.3.296.

DOI:10.1093/rheumatology/25.3.296
PMID:3730739
Abstract

A 21-year-old female is described who developed severe cerebral lupus 9 months after the onset of her disease. A dramatic change in her CT brain scan from normal to gross cerebral atrophy was observed in the month following onset of her cerebral disease. This patient developed hepatitis during the course of her hospitalization. This is an unusual manifestation of systemic lupus. The patient's serum also contained anti-Sm antibodies. This is a relatively infrequent finding in the serum of lupus patients outside the United States.

摘要

本文描述了一名21岁女性,在患病9个月后出现严重的狼疮脑病。在其脑病发作后的一个月内,观察到她的脑部CT扫描结果从正常急剧变为严重脑萎缩。该患者在住院期间出现了肝炎。这是系统性红斑狼疮的一种不寻常表现。患者血清中还含有抗Sm抗体。在美国以外的狼疮患者血清中,这是相对罕见的发现。

相似文献

1
Rapid development of cerebral atrophy in systemic lupus erythematosus.系统性红斑狼疮中脑萎缩的快速发展
Br J Rheumatol. 1986 Aug;25(3):296-9. doi: 10.1093/rheumatology/25.3.296.
2
Association of anti-Sm antibodies with organic brain syndrome secondary to systemic lupus erythematosus.
Lancet. 1994 Mar 26;343(8900):796. doi: 10.1016/s0140-6736(94)91875-9.
3
[Correlation of Sm antibodies and clinical symptoms in systemic lupus erythematosus].[系统性红斑狼疮中Sm抗体与临床症状的相关性]
Dermatol Monatsschr. 1988;174(11):667-70.
4
Autoantibodies to the Sm antigen: immunological approach to clinical aspects of systemic lupus erythematosus.抗Sm抗原自身抗体:系统性红斑狼疮临床方面的免疫学研究方法
J Rheumatol Suppl. 1987 Jun;14 Suppl 13:188-93.
5
Immunization of mice with purified U1 small nuclear ribonucleoprotein (RNP) induces a pattern of antibody specificities characteristic of the anti-Sm and anti-RNP autoimmune response of patients with lupus erythematosus, as measured by monoclonal antibodies.用纯化的U1小核核糖核蛋白(RNP)免疫小鼠,通过单克隆抗体检测发现,诱导出了红斑狼疮患者抗Sm和抗RNP自身免疫反应所特有的抗体特异性模式。
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8689-93. doi: 10.1073/pnas.83.22.8689.
6
[Clinical significance of antibodies to SM and RNP].[抗SM和RNP抗体的临床意义]
Harefuah. 1988 Feb 1;114(3):140-3.
7
Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus.系统性红斑狼疮中从Sm到核糖核蛋白反应性的时间变化。
Arthritis Rheum. 1985 Dec;28(12):1348-55. doi: 10.1002/art.1780281206.
8
Development of anti-Sm and anti-DNA antibodies followed by clinical manifestation of systemic lupus erythematosus in an elderly woman with long-standing Sjögren's syndrome.一名患有长期干燥综合征的老年女性出现抗Sm和抗DNA抗体,随后出现系统性红斑狼疮的临床表现。
Lupus. 1995 Feb;4(1):63-5. doi: 10.1177/096120339500400113.
9
Coexistence of serum anti-DNA topoisomerase I and anti-Sm antibodies: report of 3 cases.血清抗DNA拓扑异构酶I抗体与抗Sm抗体并存:3例报告
J Rheumatol. 1997 Feb;24(2):400-3.
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Anti-Sm autoantibodies in systemic lupus erythematosus mice: a model system for disease-specific autoreactivity.系统性红斑狼疮小鼠中的抗Sm自身抗体:疾病特异性自身反应性的模型系统
Springer Semin Immunopathol. 1992;14(2):127-39. doi: 10.1007/BF00195290.

引用本文的文献

1
Expression of an interspecies idiotype in sera of SLE patients and their first-degree relatives.种间独特型在系统性红斑狼疮患者及其一级亲属血清中的表达。
Clin Exp Immunol. 1988 Mar;71(3):445-50.
2
Specificity of anti-Sm antibodies by ELISA for systemic lupus erythematosus: increased sensitivity of detection using purified peptide antigens.酶联免疫吸附测定法检测系统性红斑狼疮抗Sm抗体的特异性:使用纯化肽抗原提高检测灵敏度
Ann Rheum Dis. 1988 Oct;47(10):820-5. doi: 10.1136/ard.47.10.820.
3
Systemic lupus erythematosus (SLE)-like syndromes associated with carbamazepine therapy.
与卡马西平治疗相关的系统性红斑狼疮(SLE)样综合征。
Drug Saf. 1991 Sep-Oct;6(5):350-60. doi: 10.2165/00002018-199106050-00005.
4
A case of diffuse lupus encephalopathy successfully treated with high-dose intravenous methylprednisolone.
Ital J Neurol Sci. 1992 Apr;13(3):247-50. doi: 10.1007/BF02224397.