Liu Yang, Li Lei, Wang Zhen, Zhang Juan, Zhou Zhou
The Affiliated Hospital of Shandong University of TCM, Jinan 250011, China.
The Affiliated Hospital of Shandong University of TCM, Jinan 250011, China; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Microvasc Res. 2023 Sep;149:104565. doi: 10.1016/j.mvr.2023.104565. Epub 2023 Jun 10.
Cardiovascular diseases are one of the leading causes of mortality in developed countries. Among cardiovascular disorders, myocardial infarction remains a life-threatening problem predisposing to the development and progression of ischemic heart failure. Ischemia/reperfusion (I/R) injury is a critical cause of myocardial injury. In recent decades, many efforts have been made to find the molecular and cellular mechanisms underlying the development of myocardial I/R injury and post-ischemic remodeling. Some of these mechanisms are mitochondrial dysfunction, metabolic alterations, inflammation, high production of ROS, and autophagy deregulation. Despite continuous efforts, myocardial I/R injury remains a major challenge in medical treatments of thrombolytic therapy, heart disease, primary percutaneous coronary intervention, and coronary arterial bypass grafting. The development of effective therapeutic strategies to reduce or prevent myocardial I/R injury is of great clinical significance.
心血管疾病是发达国家主要的死亡原因之一。在心血管疾病中,心肌梗死仍然是一个危及生命的问题,易引发缺血性心力衰竭的发生和发展。缺血/再灌注(I/R)损伤是心肌损伤的关键原因。近几十年来,人们为寻找心肌I/R损伤和缺血后重塑发生发展的分子和细胞机制做出了许多努力。其中一些机制包括线粒体功能障碍、代谢改变、炎症、活性氧的大量产生以及自噬失调。尽管不断努力,但心肌I/R损伤在溶栓治疗、心脏病、直接经皮冠状动脉介入治疗和冠状动脉旁路移植术的医学治疗中仍然是一个重大挑战。开发有效的治疗策略以减少或预防心肌I/R损伤具有重要的临床意义。