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雷公藤内酯醇通过抑制 ODC1 减轻肠易激综合征。

Triptolide attenuates irritable bowel syndrome via inhibiting ODC1.

机构信息

Department of Cardiology, The Third Affiliated Hospital of Shanghai University (Wenzhou People's Hospital), The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, No. 299 Guan Road, Wenzhou, 325000, Zhejiang Province, People's Republic of China.

Department of General Practice, The Third Affiliated Hospital of Shanghai University (Wenzhou People's Hospital), The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, No. 299 Guan Road, Wenzhou, 325000, Zhejiang Province, People's Republic of China.

出版信息

BMC Gastroenterol. 2023 Jun 12;23(1):202. doi: 10.1186/s12876-023-02847-8.

DOI:10.1186/s12876-023-02847-8
PMID:37308808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10258977/
Abstract

BACKGROUND

Irritable bowel syndrome (IBS) is a chronic disorder of the gut-brain axis with significant morbidity. Triptolide, an active compound extracted from Tripterygium wilfordii Hook F (TwHF), has been widely used as a major medicinal herb in the treatment of inflammatory disease.

METHODS

The chronic-acute combined stress (CAS) stimulation was used to establish IBS rat model. The model rats were then gavaged with triptolide. Forced swimming, marble-burying, fecal weight and abdominal withdrawal reflex (AWR) score were recorded. Pathologic changes in the ileal and colonic tissues were validated by hematoxylin and eosin staining. The inflammatory cytokines and Ornithine Decarboxylase-1 (ODC1) in the ileal and colonic tissues were performed by ELISA and WB.

RESULTS

Triptolide didn't have antidepressant- and antianxiety- effects in rats caused by CAS, but decreased fecal weight and AWR score. In addition, Triptolide reduced the release of IL-1, IL-6, and TNF-α and the expression of ODC1 in the ileum and colon.

CONCLUSION

The therapeutic efficacy of triptolide for IBS induced by CAS was revealed in this study, which may be related to the reduction of ODC1.

摘要

背景

肠易激综合征（IBS）是一种与脑-肠轴相关的慢性疾病，发病率较高。雷公藤红素是从雷公藤（TwHF）中提取的一种活性化合物，已被广泛用作治疗炎症性疾病的主要药物。

方法

采用慢性-急性复合应激（CAS）刺激建立 IBS 大鼠模型。然后用雷公藤红素灌胃模型大鼠。记录强迫游泳、埋珠、粪便重量和腹缩反射（AWR）评分。通过苏木精和伊红染色验证回肠和结肠组织的病理变化。通过 ELISA 和 WB 检测回肠和结肠组织中的炎性细胞因子和鸟氨酸脱羧酶-1（ODC1）。

结果

雷公藤红素对 CAS 引起的大鼠的抗抑郁和抗焦虑作用无影响，但可降低粪便重量和 AWR 评分。此外，雷公藤红素降低了回肠和结肠中 IL-1、IL-6 和 TNF-α的释放以及 ODC1 的表达。

结论

本研究揭示了雷公藤红素治疗 CAS 诱导的 IBS 的疗效，这可能与 ODC1 的减少有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/e308df9fca66/12876_2023_2847_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/0c23a5c02541/12876_2023_2847_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/d9416ed4742d/12876_2023_2847_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/120845522c18/12876_2023_2847_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/1fa6849a2330/12876_2023_2847_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/e308df9fca66/12876_2023_2847_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/0c23a5c02541/12876_2023_2847_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/d9416ed4742d/12876_2023_2847_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/120845522c18/12876_2023_2847_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/1fa6849a2330/12876_2023_2847_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0f/10258977/e308df9fca66/12876_2023_2847_Fig5_HTML.jpg

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