Department of Community Medicine, School of Medicine and Dentistry, University of Dodoma, Dodoma, Tanzania.
Department of Pathology, School of Health Sciences, Soroti University, P. O. Box 211, Soroti, Uganda.
Int Health. 2024 Mar 4;16(2):200-207. doi: 10.1093/inthealth/ihad042.
Low medication adherence among patients with type 2 diabetes mellitus (T2DM) is associated with significant morbidity and mortality globally. We investigated the prevalence of low medication adherence and its associated factors among patients with T2DM.
We used the Bengali version of the 8-item Morisky Medication Adherence Scale (MMAS-8) in measuring medication adherence among patients with T2DM who were attending the diabetes clinic at Amana Regional Referral Hospital in Dar es Salaam, Tanzania, from December 2021 to May 2022. Binary logistic regression analysis under multivariate analysis was used to determine the predictors of low medication adherence after controlling for confounders. A two-tailed p-value <0.05 was considered significant.
The prevalence of low medication adherence was 36.7% (91/248) of the subjects included in the study. Lack of formal education (adjusted odds ratio [AOR] 5.3 [95% confidence interval {CI} 1.717 to 16.312], p=0.004), having comorbidities (AOR 2.1 [95% CI 1.134 to 3.949], p=0.019) and drinking alcohol (AOR 3.5 [95% CI 1.603 to 7.650], p=0.031) were the independent predictors of low medication adherence.
More than one-third of the patients with T2DM in this study had low medication adherence. Our study also showed that a lack of formal education, having comorbidities and drinking alcohol were significantly associated with low medication adherence.
全球范围内，2 型糖尿病（T2DM）患者的药物治疗依从性低与显著的发病率和死亡率相关。我们调查了 T2DM 患者药物治疗依从性低的流行情况及其相关因素。
我们在 2021 年 12 月至 2022 年 5 月期间，使用孟加拉语版的 8 项 Morisky 药物治疗依从性量表（MMAS-8），对在坦桑尼亚达累斯萨拉姆的 Amana 地区转诊医院糖尿病诊所就诊的 T2DM 患者进行了药物治疗依从性的测量。在控制了混杂因素后，采用多变量分析中的二元逻辑回归分析来确定药物治疗依从性低的预测因素。双侧 p 值 <0.05 被认为具有统计学意义。
在所纳入的 248 例研究对象中，药物治疗依从性低的比例为 36.7%（91/248）。缺乏正规教育（调整后的优势比 [AOR] 5.3 [95%置信区间 {CI} 1.717 至 16.312]，p=0.004）、合并症（AOR 2.1 [95% CI 1.134 至 3.949]，p=0.019）和饮酒（AOR 3.5 [95% CI 1.603 至 7.650]，p=0.031）是药物治疗依从性低的独立预测因素。
在这项研究中，超过三分之一的 T2DM 患者药物治疗依从性低。我们的研究还表明，缺乏正规教育、合并症和饮酒与药物治疗依从性低显著相关。
