Dagnew Samuel Berihun, Wondm Samuel Agegnew, Dagnew Fisseha Nigussie, Yimer Yohannes Shumet, Wondmkun Yehualashet Teshome, Moges Tilaye Arega
Clinical Pharmacy Unit, School of Pharmacy, College Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Clinical Pharmacy Unit, School of Pharmacy, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Front Pharmacol. 2024 Jul 30;15:1422703. doi: 10.3389/fphar.2024.1422703. eCollection 2024.
Non-adherence to medication in patients with cardiovascular disease continues to be a main cause of suboptimal management, increased morbidity and mortality, and increased healthcare expenses. The present study assessed the level of medication adherence and its determinants of cardiovascular disease patients.
An institutional-based multicenter cross-sectional study was conducted with patients with cardiovascular disease in Northwest Ethiopian teaching hospitals. The level of medication adherence was evaluated using a standardized questionnaire of the Adherence in Chronic Disease Scale (ACDS). To find determinants of the level of medication adherence, an ordinal logistic regression model was employed. Statistics were significant when P ≤ 0.05 at a 95% confidence interval (CI).
In the end, 336 participants were included in the research. According to this study, one-third of patients had low medication adherence, half had medium adherence, and one-fifth had high medication adherence. Elderly patients [adjusted odds ratio (AOR) = 2.691; 95% confidence interval (CI), 1.704-4.251; P < 0.000], marital status (AOR = 1.921; 95% CI, 1.214-3.039; P = 0.005), alcoholic patients (AOR = 2.782; 95% CI, 1.745-4.435; P < 0.000), Patients without physical activity (AOR = 1.987; 95% CI 1.251-3.156; P = 0.004), non health insurances (AOR = 1.593; 95% CI 1.003-2.529; P = 0.049), sever Charles comorbidity index (AOR = 2.486; 95% CI 1.103-5.604; P = 0.028), patients with polypharmacy (AOR = 2.998 (1.817-4.947) P < 0.000) and, manypolypharmacy (AOR = 3.031 (1.331-6.898) P = 0.008) were more likely to have low medication adherence.
The current study concluded that one-third of study participants had low medication adherence. Older age, marital status, drinker, physical inactivity, drug source, comorbidity, and polypharmacy all contributed to the low level of medication adherence. To improve patients with cardiovascular disease's adherence to their medications, intervention is necessary.
心血管疾病患者不坚持服药仍然是治疗效果欠佳、发病率和死亡率增加以及医疗费用增加的主要原因。本研究评估了心血管疾病患者的药物依从性水平及其决定因素。
在埃塞俄比亚西北部教学医院对心血管疾病患者进行了一项基于机构的多中心横断面研究。使用慢性病依从性量表（ACDS）的标准化问卷评估药物依从性水平。为了找出药物依从性水平的决定因素，采用了有序逻辑回归模型。当在95%置信区间（CI）下P≤0.05时，统计结果具有显著性。
最终，336名参与者被纳入研究。根据本研究，三分之一的患者药物依从性低，一半患者依从性中等，五分之一患者依从性高。老年患者[调整优势比（AOR）=2.691；95%置信区间（CI），1.704 - 4.251；P<0.000]、婚姻状况（AOR = 1.921；95% CI，1.214 - 3.039；P = 0.005）、酗酒患者（AOR = 2.782；95% CI，1.745 - 4.435；P<0.000）、缺乏体育活动的患者（AOR = 1.987；95% CI 1.251 - 3.156；P = 0.004）、没有医疗保险的患者（AOR = 1.593；95% CI 1.003 - 2.529；P = 0.049）、严重的查尔斯合并症指数（AOR = 2.486；95% CI 1.103 - 5.604；P = 0.028）、服用多种药物的患者（AOR = 2.998（1.817 - 4.947）P<0.000）以及服用多种复杂药物的患者（AOR = 3.031（1.331 - 6.898）P = 0.008）更有可能药物依从性低。
当前研究得出结论，三分之一的研究参与者药物依从性低。年龄较大、婚姻状况、饮酒、缺乏体育活动、药物来源、合并症和服用多种药物均导致药物依从性水平较低。为提高心血管疾病患者的药物依从性，有必要进行干预。
