Department of Anesthesia Technology, College of Health and Medical Technology-Baghdad, Middle Technical University, Baghdad, Iraq.
Department of Physiology, College of Veterinary Medicine, Basra University, Basra, Iraq.
Arch Razi Inst. 2023 Feb 28;78(1):145-150. doi: 10.22092/ARI.2022.358488.2229. eCollection 2023 Feb.
Diabetes mellitus (DM) is a collection of metabolic illnesses known as chronic hyperglycaemia. It is one of the most common chronic diseases caused by insulin functions or secretions deficiency, which may cause carbohydrate and lipoprotein metabolism to be disrupted. The pituitary-gonadal axis malfunctions, testicular tissue dysfunctions and poor quality of sperms are all symptoms of DM, which is one of the most common causes of reproductive abnormalities. The current study has been designed to demonstrate the impacts of treatment with Ginseng oil oxidative stress-induced physiological and histological alterations in the male reproductive system of rats with subcutaneous (s/c) injection alloxan. The study was done on 30 mature male Wistar rats randomly divided into three equal groups (n=10). The first group, which served as the negative control, the second group (positive control) injection with (s/c) a single alloxan dosage (120 milligrams per kilogram of body weight), the third group was given alloxan and treated with ginseng oil (0.5cc at dosage (5 g /kg body weight daily) for 30 days. The percentage of live sperms increased significantly (≤0.05) in the group that was given Ginseng oil orally compared to the alloxan group, the percentage of dead sperms and sperm abnormalities dropped, and the total sperm count was decreased. In the rat testis, (s/c) given alloxan (120 mg/kg), aberrant spermatids were present with a decrease in the sperm numbers in the lumens of seminiferous tubules, as well as a division in the irregular germ cells. The current study concluded that Ginseng oil exerted an antioxidant effect on the male reproductive system of rats injected with subcutaneous (s/c) alloxan.
糖尿病（DM）是一组代谢疾病，以慢性高血糖为特征。它是由胰岛素功能或分泌不足引起的最常见的慢性疾病之一，可能导致碳水化合物和脂蛋白代谢紊乱。垂体-性腺轴功能障碍、睾丸组织功能障碍和精子质量差都是糖尿病的症状，糖尿病是生殖异常最常见的原因之一。本研究旨在展示氧化应激诱导的人参油对皮下（s/c）注射链脲佐菌素的雄性大鼠生殖系统的生理和组织学改变的影响。该研究在 30 只成熟雄性 Wistar 大鼠上进行，随机分为三组（n=10）。第一组作为阴性对照，第二组（阳性对照）注射（s/c）单次链脲佐菌素剂量（120 毫克/千克体重），第三组给予链脲佐菌素并给予人参油（0.5cc 剂量（5 g /kg 体重）每日）治疗 30 天。与链脲佐菌素组相比，口服给予人参油的组活精子百分比显著增加（≤0.05），死精子和精子异常百分比下降，总精子数减少。在大鼠睾丸中，（s/c）给予链脲佐菌素（120 mg/kg），存在异常精子，生精小管管腔中的精子数量减少，以及不规则生精细胞分裂。本研究得出结论，人参油对皮下（s/c）注射链脲佐菌素的雄性大鼠生殖系统具有抗氧化作用。
