Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Pazhou Lab, Guangzhou, 510330, China.
Chem Commun (Camb). 2023 Jun 29;59(53):8238-8241. doi: 10.1039/d3cc01760e.
The triple -defluoroetherification of (trifluoromethyl)alkenes with fluoroalkylated alcohols by C(sp)-F bond cleavage is reported, delivering various fluoroalkylated orthoesters in high yields. This reaction is transition-metal free and gram-scalable, features mild reaction conditions, and tolerates diverse functional groups.
报告了通过 C(sp)-F 键断裂，（三氟甲基）烯烃与全氟烷基醇的三氟代醚化反应，以高产率得到各种全氟烷基邻位酯。该反应无需过渡金属且可规模化，具有温和的反应条件，且可耐受多种官能团。
