Integrative Medicine Institute, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Chinese Center for Disease Control and Prevention, Beijing, China.
BMC Pediatr. 2023 Jun 15;23(1):292. doi: 10.1186/s12887-023-04122-x.
Thrombosis is a serious condition in children and neonates. However, the risk factors for thrombosis have not been conclusively determined. This study aimed to identify the risk factors for thrombosis in children and neonates in Intensive Care Unit (ICU) through a meta-analysis to better guide clinical treatment.
A systematic search of electronic databases (PubMed, Embase, Cochrane Library, WOS, CNKI, Wanfang, VIP) was conducted to retrieve studies from creation on 23 May 2022. Data on the year of publication, study design, country of origin, number of patients/controls, ethnicity, and type of thrombus were extracted. The publication bias and heterogeneity between studies were assessed, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed or random effects models.
A total of 18 studies met the inclusion criteria. The incidence of thrombosis in children was 2% per year (95% CI 1%-2%, P < 0.01). Infection and sepsis (OR = 1.95, P < 0.01), CVC (OR = 3.66, [95%CL 1.78-7.51], P < 0.01), mechanical ventilation (OR = 2.1, [95%CL1.47-3.01], P < 0.01), surgery (OR = 2.25, [95%CL1.2-4.22], P < 0.01), respiratory distress (OR = 1.39, [95%CL0.42-4.63], P < 0.01), ethnicities (OR = 0.88, [95%CL 0.79-0.98], P = 0.78), gestational age (OR = 1.5, [95%CL1.34-1.68], P = 0.65)were identified as risk factors for thrombosis.
This meta-analysis suggests that CVC, Surgery, mechanical ventilation, Infection/sepsis, gestational age, Respiratory distress, and different ethnicities are risk factors for thrombosis in children and neonates in ICU. These findings may help clinicians to identify high-risk patients and develop appropriate prevention strategies.
PROSPERO (CRD 42022333449).
血栓形成是儿童和新生儿的严重病症。然而，血栓形成的风险因素尚未确定。本研究旨在通过荟萃分析确定儿童和新生儿重症监护病房（ICU）中血栓形成的风险因素，以便更好地指导临床治疗。
系统检索电子数据库（PubMed、Embase、Cochrane Library、WOS、CNKI、万方、VIP），以检索截至 2022 年 5 月 23 日的研究。提取研究的出版年份、研究设计、来源国、患者/对照例数、种族和血栓类型的数据。评估研究之间的发表偏倚和异质性，并使用固定或随机效应模型计算合并的优势比（OR）和 95%置信区间（CI）。
共有 18 项研究符合纳入标准。儿童血栓形成的发生率为每年 2%（95%CI 1%-2%，P<0.01）。感染和败血症（OR=1.95，P<0.01）、CVC（OR=3.66，95%CI 1.78-7.51，P<0.01）、机械通气（OR=2.1，95%CI 1.47-3.01，P<0.01）、手术（OR=2.25，95%CI 1.2-4.22，P<0.01）、呼吸窘迫（OR=1.39，95%CI 0.42-4.63，P<0.01）、种族（OR=0.88，95%CI 0.79-0.98，P=0.78）和胎龄（OR=1.5，95%CI 1.34-1.68，P=0.65）被确定为血栓形成的危险因素。
这项荟萃分析表明，CVC、手术、机械通气、感染/败血症、胎龄、呼吸窘迫和不同种族是儿童和新生儿 ICU 中血栓形成的危险因素。这些发现可能有助于临床医生识别高危患者并制定适当的预防策略。
PROSPERO（CRD42022333449）。
