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用于电子束熔炼定制植入物治疗骨癌的混合实体网格结构

Hybrid solid mesh structure for electron beam melting customized implant to treat bone cancer.

作者信息

Park Jong Woong, Seo Eunhyeok, Park Haeum, Shin Ye Chan, Kang Hyun Guy, Sung Hyokyung, Jung Im Doo

机构信息

Orthopaedic Oncology Clinic, Center for Rare Cancers, National Cancer Center, Goyang 10408, Republic of Korea.

Surgical Oncology Branch, Division of Clinical Research, National Cancer Center, Goyang 10408, Republic of Korea.

出版信息

Int J Bioprint. 2023 Mar 21;9(4):716. doi: 10.18063/ijb.716. eCollection 2023.

DOI:10.18063/ijb.716
PMID:37323484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10261134/
Abstract

15Bone replacement implants manufactured by electron beam melting have been widely studied for use in bone tumor treatment. In this application, a hybrid structure implant with a combination of solid and lattice structures guarantees strong adhesion between bone and soft tissues. This hybrid implant must exhibit adequate mechanical performance so as to satisfy the safety criteria considering repeated weight loading during the patient's lifetime. With a low volume of a clinical case, various shape and volume combinations, including both solid and lattice structures, should be evaluated to provide guidelines for implant design. This study examined the mechanical performance of the hybrid lattice by investigating two shapes of the hybrid implant and volume fractions of the solid and lattice structures, along with microstructural, mechanical, and computational analyses. These results demonstrate how hybrid implants may be designed to improve clinical outcomes by using patient-specific orthopedic implants with optimized volume fraction of the lattice structure, allowing for effective enhancement of mechanical performance as well as optimized design for bone cell ingrowth.

摘要

通过电子束熔炼制造的骨替代植入物已被广泛研究用于骨肿瘤治疗。在这种应用中，具有实体和晶格结构组合的混合结构植入物可确保骨骼与软组织之间的强附着力。这种混合植入物必须表现出足够的机械性能，以便在考虑患者一生中反复承受体重负荷的情况下满足安全标准。由于临床病例数量较少，应评估包括实体和晶格结构在内的各种形状和体积组合，以为植入物设计提供指导。本研究通过研究两种形状的混合植入物以及实体和晶格结构的体积分数，结合微观结构、力学和计算分析，考察了混合晶格的力学性能。这些结果表明，如何通过使用具有优化晶格结构体积分数的患者特异性骨科植入物来设计混合植入物，以改善临床结果，从而有效提高机械性能，并为骨细胞向内生长进行优化设计。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a8/10261134/d9f0ccdc5623/IJB-9-4-716-g012.jpg
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本文引用的文献

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Int J Bioprint. 2022 Jan 12;8(1):478. doi: 10.18063/ijb.v8i1.478. eCollection 2022.
2
Transepiphyseal resection for osteosarcoma in patients with open physes using MRI assessment.MRI 评估下干骺端开放的骨肉瘤患者经干骺端骨切除
Bone Joint J. 2020 Jun;102-B(6):772-778. doi: 10.1302/0301-620X.102B6.BJJ-2019-1141.R2.
3
New 3-dimensional implant application as an alternative to allograft in limb salvage surgery: a technical note on 10 cases.
新型三维植入物在保肢手术中替代同种异体移植的应用：10例技术说明
Acta Orthop. 2020 Aug;91(4):489-496. doi: 10.1080/17453674.2020.1755543. Epub 2020 May 12.
4
The application of 3D-printing technology in pelvic bone tumor surgery.3D 打印技术在骨盆骨肿瘤手术中的应用。
J Orthop Sci. 2021 Mar;26(2):276-283. doi: 10.1016/j.jos.2020.03.004. Epub 2020 Apr 1.
5
Additive manufacturing of ultrafine-grained high-strength titanium alloys.增材制造超细晶高强钛合金。
Nature. 2019 Dec;576(7785):91-95. doi: 10.1038/s41586-019-1783-1. Epub 2019 Dec 4.
6
Three-dimension-printed custom-made prosthetic reconstructions: from revision surgery to oncologic reconstructions.三维打印定制假体重建：从翻修手术到肿瘤重建。
Int Orthop. 2019 Jan;43(1):123-132. doi: 10.1007/s00264-018-4232-0. Epub 2018 Nov 22.
7
Bone tumor resection guide using three-dimensional printing for limb salvage surgery.用于保肢手术的三维打印骨肿瘤切除指南
J Surg Oncol. 2018 Nov;118(6):898-905. doi: 10.1002/jso.25236. Epub 2018 Sep 27.
8
Three-Dimensionally Printed Personalized Implant Design and Reconstructive Surgery for a Bone Tumor of the Calcaneus: A Case Report.三维打印个性化植入物设计及跟骨骨肿瘤重建手术：一例报告
JBJS Case Connect. 2018 Apr-Jun;8(2):e25. doi: 10.2106/JBJS.CC.17.00212.
9
Bony ingrowth potential of 3D-printed porous titanium alloy: a direct comparison of interbody cage materials in an in vivo ovine lumbar fusion model.3D 打印多孔钛合金的骨内生长潜力：体内羊腰椎融合模型中椎间笼材料的直接比较。
Spine J. 2018 Jul;18(7):1250-1260. doi: 10.1016/j.spinee.2018.02.018. Epub 2018 Feb 26.
10
One-step volumetric additive manufacturing of complex polymer structures.复杂聚合物结构的一步式体积增材制造。
Sci Adv. 2017 Dec 8;3(12):eaao5496. doi: 10.1126/sciadv.aao5496. eCollection 2017 Dec.