Leng Fang, Zheng Mengjia, Xu Chenjie
Department of Biomedical Engineering City University of Hong Kong Kowloon Hong Kong SAR P. R. China.
Exploration (Beijing). 2021 Dec 28;1(3):20210109. doi: 10.1002/EXP.20210109. eCollection 2021 Dec.
Microneedles (MNs) offer a simple and minimally invasive way to sample skin interstitial fluid for bioanalysis. Through the integration with portable or wearable sensing devices, it allows us to get qualitative information about some biomarkers in situ. This work is to show a MN platform with open groove channels that are manufactured using photopolymerization 3D printing. The grooves on the needle surface permit that liquid flows from the tips to the base under the influence of capillary force. The ultimate MN device can penetrate skin and tissues and sample liquid in the skin model. By taking the glucose as the model biomarker, we demonstrate that the biomarkers in the extracted liquid can be analyzed in situ by the commercial test strips attached to the back.
微针（MNs）为生物分析采集皮肤间质液提供了一种简单且微创的方法。通过与便携式或可穿戴传感设备集成，它使我们能够原位获取有关某些生物标志物的定性信息。这项工作旨在展示一种具有开放凹槽通道的微针平台，该平台是使用光聚合3D打印制造的。针表面的凹槽使液体在毛细作用力的影响下从针尖流向针基部。最终的微针装置能够穿透皮肤和组织，并在皮肤模型中采集液体。以葡萄糖作为模型生物标志物，我们证明了所提取液体中的生物标志物可通过附着在背面的商用测试条进行原位分析。
