Garcez Patricia P, Guasti André, Ventura Nina, Higa Luiza Mendonça, Andreiuolo Felipe, de Freitas Gabriella Pinheiro A, Ribeiro Liane de Jesus, Maia Richard Araújo, de Lima Sheila Maria Barbosa, de Souza Azevedo Adriana, Schwarcz Waleska Dias, Caride Elena Cristina, Chimelli Leila, Dubois Luiz Gustavo, Ferreira Júnior Orlando da Costa, Tanuri Amilcar, Moura-Neto Vivaldo, Niemeyer Paulo
Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil.
Front Med (Lausanne). 2023 Jun 1;10:1192070. doi: 10.3389/fmed.2023.1192070. eCollection 2023.
Glioblastoma is the most frequent and aggressive primary brain cancer. In preclinical studies, Zika virus, a flavivirus that triggers the death of glioblastoma stem-like cells. However, the flavivirus oncolytic activity has not been demonstrated in human patients. Here we report a glioblastoma patient who received the standard of care therapy, including surgical resection, radiotherapy and temozolomide. However, shortly after the tumor mass resection, the patient was clinically diagnosed with a typical arbovirus-like infection, during a Zika virus outbreak in Brazil. Following the infection resolution, the glioblastoma regressed, and no recurrence was observed. This clinical response continues 6 years after the glioblastoma initial diagnosis.
胶质母细胞瘤是最常见且侵袭性最强的原发性脑癌。在临床前研究中，寨卡病毒（一种黄病毒）可引发胶质母细胞瘤干细胞样细胞死亡。然而，这种黄病毒的溶瘤活性尚未在人类患者中得到证实。在此，我们报告一名胶质母细胞瘤患者，其接受了包括手术切除、放疗和替莫唑胺在内的标准治疗。然而，在肿瘤肿块切除后不久，在巴西寨卡病毒爆发期间，该患者被临床诊断为典型的虫媒病毒样感染。感染消退后，胶质母细胞瘤消退，且未观察到复发。胶质母细胞瘤初次诊断6年后，这种临床反应仍在持续。
