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Cantharidin biosynthesis in a blister beetle: inhibition by 6-fluoromevalonate causes chemical disarmament.

作者信息

Carrel J E, Doom J P, McCormick J P

出版信息

Experientia. 1986 Jul 15;42(7):853-4. doi: 10.1007/BF01941552.

DOI:10.1007/BF01941552
PMID:3732495
Abstract

Biosynthesis of cantharidin in a blister beetle, Lytta polita, is effectively inhibited by 6-fluoromevalonate. Inhibition is attributed specifically to the fluorine substituent. Biochemical inhibition has not been demonstrated previously for an arthropod's defensive substance.

摘要

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引用本文的文献

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2
Male Accessory Glands of Blister Beetles and Cantharidin Release: A Comparative Ultrastructural Analysis.芫菁雄性附腺与斑蝥素释放：比较超微结构分析
Insects. 2022 Jan 26;13(2):132. doi: 10.3390/insects13020132.
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Unraveling the role of male reproductive tract and haemolymph in cantharidin-exuding Lydus trimaculatus and Mylabris variabilis (Coleoptera: Meloidae): a comparative transcriptomics approach.

本文引用的文献

1
Cantharidin: potent feeding deterrent to insects.斑蝥素：对昆虫有强效的取食威慑作用。
Science. 1974 Feb 22;183(4126):755-7. doi: 10.1126/science.183.4126.755.
2
Mechanism of the inhibition of cholesterol biosynthesis by 6-fluoromevalonate.6-氟甲羟戊酸抑制胆固醇生物合成的机制
Biochem J. 1985 Apr 1;227(1):247-54. doi: 10.1042/bj2270247.
3
[Identification of farnesol as an intermediate in the biosynthesis of cantharidin from mevalonolactone].[法尼醇作为从甲羟戊酸内酯生物合成斑蝥素的中间体的鉴定]
解析芫菁科丽芫菁和黄黑小斑芫菁雄性生殖管和血淋巴在斑蝥素分泌中的作用：比较转录组学方法。
BMC Genomics. 2021 Nov 8;22(1):808. doi: 10.1186/s12864-021-08118-8.
4
Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine.来自中药药用甲虫的药物发现见解
Biomol Ther (Seoul). 2021 Mar 1;29(2):105-126. doi: 10.4062/biomolther.2020.229.
5
Draft Genome of a Blister Beetle .一种芫菁的基因组草图
Front Genet. 2020 Jan 8;10:1281. doi: 10.3389/fgene.2019.01281. eCollection 2019.
6
Draft genomes of two blister beetles Hycleus cichorii and Hycleus phaleratus.两型黄守瓜 Hycleus cichorii 和 Hycleus phaleratus 的基因组草图。
Gigascience. 2018 Mar 1;7(3):1-7. doi: 10.1093/gigascience/giy006.
7
Characterization of Juvenile Hormone Related Genes Regulating Cantharidin Biosynthesis in Epicauta chinensis.鉴定调控中国龙虱芫菁素生物合成的保幼激素相关基因。
Sci Rep. 2017 May 23;7(1):2308. doi: 10.1038/s41598-017-02393-w.
8
The Potential Organ Involved in Cantharidin Biosynthesis in Epicauta chinensis Laporte (Coleoptera: Meloidae).中华豆芫菁（鞘翅目：芫菁科）中斑蝥素生物合成可能涉及的器官。
J Insect Sci. 2017 Jan 1;17(2). doi: 10.1093/jisesa/iex021.
9
De Novo Transcriptome and Expression Profile Analysis to Reveal Genes and Pathways Potentially Involved in Cantharidin Biosynthesis in the Blister Beetle Mylabris cichorii.从头转录组和表达谱分析以揭示可能参与斑蝥芫菁斑蝥素生物合成的基因和途径
PLoS One. 2016 Jan 11;11(1):e0146953. doi: 10.1371/journal.pone.0146953. eCollection 2016.
Helv Chim Acta. 1977 Dec 14;60(8):2756-62. doi: 10.1002/hlca.19770600827.