Wright L C, May G L, Dyne M, Mountford C E
FEBS Lett. 1986 Jul 28;203(2):164-8. doi: 10.1016/0014-5793(86)80735-9.
High-resolution proton nuclear magnetic resonance studies show that the spectrum of a proteolipid complex, isolated from the serum of patients with malignant diseases, is directly comparable with that obtained from intact cancer cells and solid tumours. These NMR signals have previously been shown to reveal differences between cancer cells with various biological characteristics such as metastatic capacity and drug sensitivity. The proteolipid contains cholesterol, phospholipid, triglyceride, glycolipids, ether-linked lipids, and an apoprotein of unusual electrophoretic mobility. We have yet to confirm the presence of the mRNA reported by others. NMR spectroscopy could be used as a rapid method of identifying the presence of this proteolipid complex in human serum and aiding the diagnosis of malignant disease.
高分辨率质子核磁共振研究表明，从恶性疾病患者血清中分离出的一种蛋白脂质复合物的光谱，与从完整癌细胞和实体瘤中获得的光谱直接可比。这些核磁共振信号此前已被证明能揭示具有不同生物学特性（如转移能力和药物敏感性）的癌细胞之间的差异。该蛋白脂质含有胆固醇、磷脂、甘油三酯、糖脂、醚连接脂质以及一种电泳迁移率异常的载脂蛋白。我们尚未证实其他人所报道的信使核糖核酸的存在。核磁共振光谱可作为一种快速方法，用于鉴定人血清中这种蛋白脂质复合物的存在，并辅助恶性疾病的诊断。
