Mountford C E, May G L, Wright L C, Mackinnon W B, Dyne M, Holmes K T, van Haaften-Day C, Tattersall M H
Lancet. 1987 Apr 11;1(8537):829-34. doi: 10.1016/s0140-6736(87)91609-6.
Magnetic resonance spectroscopy (MRS) can identify abnormal lipoproteins in the plasma of patients with premalignant and malignant tumours. Proteolipid complexes, 8-11 nm and 25-28 nm in size, were isolated from the plasma of a patient with a borderline ovarian tumour. These complexes, which generated a characteristically long MRS T2 relaxation value (greater than 400 ms), were disrupted by ribonuclease. None of the conventional lipoproteins had a T2 value above 160 ms. Chemical analysis of the proteolipid complexes showed a 20% glycolipid component, and MRS identified a fucosylated molecule as the origin of the long T2 value. 9 months after resection of all tumour, a visible lipoprotein band, possibly lipoprotein (a), persisted in the plasma but neither the long T2 relaxation value nor the 8-11 nm or 25-28 nm particles were present. The long T2 relaxation value in the MRS profile, found in isolated proteolipid and unfractionated plasma and serum of other patients with carcinoma of the ovary and colon, provides a non-invasive method of assaying for cancer.
磁共振波谱法（MRS）能够识别癌前和恶性肿瘤患者血浆中的异常脂蛋白。从一名交界性卵巢肿瘤患者的血浆中分离出了大小为8 - 11纳米和25 - 28纳米的蛋白脂质复合物。这些复合物产生了特征性的长MRS T2弛豫值（大于400毫秒），并被核糖核酸酶破坏。没有一种传统脂蛋白的T2值高于160毫秒。对蛋白脂质复合物的化学分析显示其含有20%的糖脂成分，且MRS鉴定出一种岩藻糖基化分子是长T2值的来源。在切除所有肿瘤9个月后，血浆中出现了一条可见的脂蛋白带，可能是脂蛋白（a），但既没有长T2弛豫值，也没有8 - 11纳米或25 - 28纳米的颗粒。在其他卵巢癌和结肠癌患者的分离蛋白脂质以及未分级血浆和血清中发现的MRS谱中的长T2弛豫值，提供了一种癌症的非侵入性检测方法。
