Wieczorek A J, Rhyner C, Block L H
Proc Natl Acad Sci U S A. 1985 May;82(10):3455-9. doi: 10.1073/pnas.82.10.3455.
An RNA-proteolipid complex was isolated from sera of patients with a variety of malignant disorders as well as from culture media of malignant cell lines. The complex, characterized by a relatively constant composition, contains 27S poly(A)+ RNA and Mr 1250 oligopeptide(s) and is rich in phospholipids and glycosphingolipids. Serum lipoproteins (low and high density) differ from this complex in density, chemical composition, and immunological reactivity. The complex was detected in 94 of 96 cases of malignancy tested but not in any of 58 patients with nonmalignant disorders or in 46 healthy individuals.
从患有各种恶性疾病患者的血清以及恶性细胞系的培养基中分离出一种RNA - 蛋白脂质复合物。该复合物具有相对恒定的组成特征，包含27S多聚腺苷酸（poly(A)+）RNA和分子量为1250的寡肽，富含磷脂和糖鞘脂。血清脂蛋白（低密度和高密度）在密度、化学成分和免疫反应性方面与该复合物不同。在所检测的96例恶性肿瘤病例中，有94例检测到该复合物，但在58例非恶性疾病患者或46名健康个体中均未检测到。
