Veyrac M, Bories P, Collet H, Parelon G, Fauroux P, Godard P, Michel H
Gastroenterol Clin Biol. 1986 May;10(5):400-4.
Fifty-five adults with asthma were explored by gastroesophageal scintigraphy (GES) and pH monitoring (3 postprandial hours, 12 nocturnal hours). For their asthma, all patients received theophylline twice a day. Associated digestive symptomatology led to investigations for gastroesophageal reflux (GER). Twelve hours pH monitoring, the reference method, was validated in 13 normal volunteers. During 12 hr pH monitoring, 4 criteria were studied: number of GER, percentage of time at pH 4, number of GER longer than 5 min and longest GER. Acid reflux occurred in 69 p. 100 of cases. Three hours postprandial pH monitoring and GES showed a GER in 40 and 47.5 p. 100 of cases (p greater than 0.05). GES revealed pulmonary aspiration in almost a quarter of asthmatic adults. Detection of a 30 p. cent increment of nocturnal GER by long pH monitoring could explain that results may differ with various techniques. Pulmonary aspiration was more frequent after longer and deeper GER. The mean duration of GER was more than 9 min but it was not significantly different from GER without pulmonary aspiration. GES may be helpful after 12 h pH monitoring because it can prove pulmonary aspiration. Its association with long and intense GER at 12 h pH monitoring suggests definitive surgical treatment of GER in asthmatic patients.
对55名成年哮喘患者进行了胃食管闪烁扫描（GES）和pH监测（餐后3小时，夜间12小时）。所有患者因哮喘每天接受两次茶碱治疗。相关的消化系统症状促使对胃食管反流（GER）进行检查。在13名正常志愿者中验证了作为参考方法的12小时pH监测。在12小时pH监测期间，研究了4项标准：GER次数、pH值低于4的时间百分比、持续时间超过5分钟的GER次数以及最长的GER时间。69%的病例出现酸反流。餐后3小时pH监测和GES显示GER的病例分别为40%和47.5%（p>0.05）。GES显示近四分之一的成年哮喘患者存在肺吸入。通过长时间pH监测检测到夜间GER增加30%，这可以解释不同技术的结果可能存在差异。GER时间越长、程度越深，肺吸入越频繁。GER的平均持续时间超过9分钟，但与无肺吸入的GER无显著差异。12小时pH监测后GES可能会有所帮助，因为它可以证实肺吸入。其与12小时pH监测时长时间强烈GER的关联表明，哮喘患者的GER应进行确定性手术治疗。
