Mattioli G, Sacco O, Gentilino V, Martino F, Pini Prato A, Castagnetti M, Montobbio G, Jasonni V
Pediatric Surgery Unit, Giannina Gaslini Research Institute, University of Genova, Largo G. Gaslini 5, 16100 Genoa, Italy.
Surg Endosc. 2004 Mar;18(3):463-5. doi: 10.1007/s00464-003-9108-7. Epub 2004 Feb 2.
The role of surgery is debated for children with gastroesophageal reflux disease (GERD), particularly when they show atypical symptoms. This study was designed to evaluate the safety and outcome of laparoscopic Nissen-Rossetti fundoplication performed in a selected population of children with gastroesophageal reflux and atypical supraesophageal symptoms.
This prospective study included 595 patients younger than 14 years with GERD who reported recurrent respiratory symptoms and had no benefit from standard medical treatment. Surgery was performed for 48 patients with anatomic anomalies, life-threatening events, or respiratory complications after ineffective medical treatment. The subjective and objective outcomes were evaluated.
No major intraoperative complications were experienced, and there was no recurrence of gastroesophageal reflux during a postoperative follow-up period of 12 months. The parents' final subjective evaluation of the outcomes 12 months after surgery was positive in 44 cases and negative in 4 cases.
Children with difficult-to-treat chronic respiratory symptoms must be evaluated for GERD, even if the need for surgery is low (8%), because complete eradication of reflux is mandatory. Radical treatment of GERD allows the pulmonologist to perform correct respiratory treatment and to prevent the development chronic and life-threatening complications.
对于患有胃食管反流病(GERD)的儿童,手术的作用存在争议,尤其是当他们表现出非典型症状时。本研究旨在评估在选定的患有胃食管反流和非典型食管上症状的儿童群体中进行腹腔镜Nissen-Rossetti胃底折叠术的安全性和结果。
这项前瞻性研究纳入了595名14岁以下患有GERD且报告有反复呼吸道症状且标准药物治疗无效的患者。对48例经药物治疗无效后出现解剖异常、危及生命事件或呼吸道并发症的患者进行了手术。评估了主观和客观结果。
术中未出现重大并发症,术后12个月随访期间胃食管反流未复发。术后12个月家长对结果的最终主观评价为44例阳性,4例阴性。
对于患有难以治疗的慢性呼吸道症状的儿童,即使手术需求较低(8%),也必须评估是否患有GERD,因为彻底消除反流是必要的。GERD的根治性治疗使肺科医生能够进行正确的呼吸治疗,并预防慢性和危及生命的并发症的发生。