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Prognostic impact of RUNX1 mutations and deletions in pediatric acute myeloid leukemia: results from the French ELAM02 study group.

作者信息

Lew-Derivry Lucille, Marceau-Renaut Alice, Fenwarth Laurène, Cuccuini Wendy, Ballerini Paola, Ferreboeuf Maxime, Guilmatre Audrey, Petit Arnaud, Gandemer Virginie, Rialland Fanny, Schneider Pascale, Michel Gérard, Bertrand Yves, Baruchel Andre, Preudhomme Claude, Leverger Guy, Lapillonne Hélène

机构信息

AP-HP, Pediatric Hematology and Oncology Department, Trousseau Hospital, F-75012, Paris, France.

CHU Lille, Laboratory of Hematology, F-59000, Lille, France.

出版信息

Leukemia. 2023 Aug;37(8):1723-1726. doi: 10.1038/s41375-023-01931-y. Epub 2023 Jun 16.

DOI:10.1038/s41375-023-01931-y
PMID:37328541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10400410/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80c/10400410/f80406f302a5/41375_2023_1931_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80c/10400410/f80406f302a5/41375_2023_1931_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80c/10400410/f80406f302a5/41375_2023_1931_Fig1_HTML.jpg

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Blood Adv. 2021 Sep 14;5(17):3254-3265. doi: 10.1182/bloodadvances.2021004556.
2
Cancer Statistics, 2021.癌症统计数据，2021.
CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12.
3
Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA).胚系转录因子突变（RUNX1、GATA2、CEBPA）患者的继发性白血病。
新型生物标志物：RUNX家族作为结直肠癌的预后预测指标
Front Immunol. 2024 Dec 9;15:1430136. doi: 10.3389/fimmu.2024.1430136. eCollection 2024.
4
Genetic Characterization of Pediatric Mixed Phenotype Acute Leukemia (MPAL).儿科混合表型急性白血病（MPAL）的遗传学特征。
Cancer Genomics Proteomics. 2024 Jan-Feb;21(1):1-11. doi: 10.21873/cgp.20424.
Blood. 2020 Jul 2;136(1):24-35. doi: 10.1182/blood.2019000937.
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RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.RUNX1 突变家族表现出表型异质性以及一种种系易感性急性髓系白血病特有的体细胞突变谱。
Blood Adv. 2020 Mar 24;4(6):1131-1144. doi: 10.1182/bloodadvances.2019000901.
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Molecular Profiling Defines Distinct Prognostic Subgroups in Childhood AML: A Report From the French ELAM02 Study Group.分子谱分析确定儿童急性髓系白血病的不同预后亚组：来自法国ELAM02研究组的报告
Hemasphere. 2018 Feb 21;2(1):e31. doi: 10.1097/HS9.0000000000000031. eCollection 2018 Jan-Feb.
6
ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.ClinGen 髓系恶性肿瘤变异体校正专家组关于胚系 RUNX1 变异体的建议。
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