VIB Center for Inflammation Research, VIB, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium; Department of Pathobiology, Pharmacology, and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
Department of Pathobiology, Pharmacology, and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
Trends Microbiol. 2023 Dec;31(12):1206-1224. doi: 10.1016/j.tim.2023.05.010. Epub 2023 Jun 15.
A growing body of research, especially in recent years, has shown that bacterial extracellular vesicles (bEVs) are one of the key underlying mechanisms behind the pathogenesis of various diseases like pulmonary fibrosis, sepsis, systemic bone loss, and Alzheimer's disease. Given these new insights, bEVs are proposed as an emerging vehicle that can be used as a diagnostic tool or to tackle diseases when used as a therapeutic target. To further boost the understanding of bEVs in health and disease we thoroughly discuss the contribution of bEVs in disease pathogenesis and the underlying mechanisms. In addition, we speculate on their potential as novel diagnostic biomarkers and how bEV-related mechanisms can be exploited as therapeutic targets.
越来越多的研究表明，特别是近年来，细菌细胞外囊泡（bEVs）是多种疾病发病机制的关键潜在机制之一，如肺纤维化、脓毒症、系统性骨质流失和阿尔茨海默病。鉴于这些新的见解，bEVs 被提议作为一种新兴的载体，可以用作诊断工具或作为治疗靶点来治疗疾病。为了进一步加深对 bEVs 在健康和疾病中的理解，我们深入讨论了 bEVs 在疾病发病机制和潜在机制中的作用。此外，我们推测它们作为新型诊断生物标志物的潜力，以及如何利用 bEV 相关机制作为治疗靶点。
